2-acetyl-5-chloro-2,3-dihydro-1H-inden-1-one | 1141699-88-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 2-acetyl-5-chloro-2,3-dihydro-1H-inden-1-one
• 英文别名: 2-acetyl-5-chloro-2,3-dihydroinden-1-one
• CAS: 1141699-88-8
• 化学式: C₁₁H₉ClO₂
• 分子量: 208.644
• InChiKey: JHYZQFAAOYBAEI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-acetyl-5-chloro-2,3-dihydro-1H-inden-1-one 在 S-联萘酚磷酸酯 、 4-氯亚硝基苯 作用下， 以 苯 为溶剂， 生成 2-acetyl-5-chloro-2-hydroxy-2,3-dihydro-1H-inden-1-one
  参考文献：
  名称：

  Lu, Min; Zhu, Di; Lu, Yunpeng, Journal of the American Chemical Society, 2009, vol. 131, p. 4562 - 4563

  摘要：

  DOI：

文献信息

• The CF₃-DAST-induced deacylative trifluoromethylthiolation of cyclic 1,3-diketones/lactams/lactones and its extension to deacylative pentafluorophenylthiolation
  作者：Ibrayim Saidalimu、Takuya Yoshioka、Yumeng Liang、Etsuko Tokunaga、Norio Shibata

  DOI：10.1039/c8cc05409f

  日期：——

  CF₃-DAST-induced deacylative trifluoromethylthiolation of cyclic 1,3-diketones lactams, and lactones that provides cyclic trifluoromethylthioketones, lactams and lactones is reported.

  CF₃-DAST诱导的环状1,3-二酮内酰胺和内酯的脱酰三氟甲硫基化反应，提供环状三氟甲硫基酮、内酰胺和内酯。
• Highly Efficient and Regioselective Allylation with Allylic Alcohols Catalyzed by [Mo₃S₄Pd(η³-allyl)] Clusters
  作者：Yinsong Tao、Bo Wang、Baomin Wang、Lihong Qu、Jingping Qu

  DOI：10.1021/ol100805c

  日期：2010.6.18

  A highly efficient and regioselective allylation reaction of amines and active methylene compounds directly using allylic alcohols under mild conditions catalyzed by the novel cubane-type sulfido [(Cp*Mo)3(μ3-S)4Pd(η3-allyl)][PF6]2 clusters has been developed. A variety of allylic alcohols and nucleophiles including amines and active methylene compounds are investigated, and in the case of allylic alcohols

  胺和直接使用由所述新颖的立方烷型硫代[（CP * Mo）的催化的温和的条件下烯丙醇的活性亚甲基化合物的高效和区域选择性烯丙基反应，3（μ 3 -S）4的Pd（η 3 -烯丙基）] [PF 6 ]已经开发了2个集群。研究了包括胺和活性亚甲基化合物在内的各种烯丙醇和亲核体，在烯丙基醇的α-或γ-位带有取代基的情况下，只能得到线性产物。
• Novel Tartrate-Based Guanidines for Enantioselective Fluorination of 1,3-Dicarbonyl and α-Cyano Carbonyl Compounds
  作者：Liwei Zou、Xiaoze Bao、Huanrui Zhang、Yuming Song、Jingping Qu、Baomin Wang

  DOI：10.1071/ch14179

  日期：——

  electronic properties. A guanidine molecule of this library with an incorporated 2,6-diisoaniline fragment was identified as a suitable promoter for the enantioselective fluorination of 1,3-dicarbonyl and α-cyano carbonyl compounds to furnish the fluorinated product with up to 84 % ee and 99 % yield using N-fluorobenzenesulfonimide (NFSI) as the fluorinating agent.

  具有酒石酸骨架的新型手性胍库具有可调节的空间和电子特性，可轻松访问。该文库中掺入2，6-二异苯胺片段的胍分子被鉴定为1,3-二羰基和α-氰基羰基化合物的对映选择性氟化的合适促进剂，可为氟化产物提供84％ee和99使用N-氟苯磺酰亚胺（NFSI）作为氟化剂的收率（％）。
• Development of Tartaric Acid Derived Chiral Guanidines and Their Application to Catalytic Enantioselective α-Hydroxylation of β-Dicarbonyl Compounds
  作者：Liwei Zou、Baomin Wang、Hongfang Mu、Huanrui Zhang、Yuming Song、Jingping Qu

  DOI：10.1021/ol401306h

  日期：2013.6.21

  A novel library of chiral guanidines featuring a tartaric acid skeleton was developed from diethyl L-tartrate. These guanidines are easily accessed with tunable style and electronic properties. The utilities of the guanidines were highlighted by their ability to catalyze the alpha-hydroxylation of beta-ketoesters and beta-diketones with remarkable efficiency and excellent enantioselectivity.