methyl 3-amino-4-cyano-1-benzylpyrrole-2-carboxylate | 587868-39-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: methyl 3-amino-4-cyano-1-benzylpyrrole-2-carboxylate
• 英文别名: methyl 3-amino-1-benzyl-4-cyano-1H-pyrrole-2-carboxylate；methyl 3-amino-1-benzyl-4-cyanopyrrole-2-carboxylate
• CAS: 587868-39-1
• 化学式: C₁₄H₁₃N₃O₂
• 分子量: 255.276
• InChiKey: PDAZCBFYUUCOQH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  81
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Pyrrolopyrimidine derivatives
  申请人：Kataoka Kenichiro

  公开号：US20050277773A1

  公开（公告）日：2005-12-15

  The invention provides pyrrolo[3,2-d]pyrimidine derivatives represented by formula (I), and their medically acceptable salts. The compounds of the invention exhibit GSK-3 inhibiting activity and are therefore expected to be useful as therapeutic or prophylactic agents for conditions in which GSK-3 is implicated, such as diabetes, diabetes complications, Alzheimer's disease, neurodegenerative diseases, manic depression, traumatic encephalopathy, alopecia, inflammatory diseases, cancer and immune deficiency.

  本发明提供了由式(I)表示的吡咯并[3,2-d]嘧啶衍生物及其医学上可接受的盐。本发明的化合物表现出GSK-3抑制活性，因此预计可用作治疗或预防与GSK-3有关的疾病的治疗或预防剂，例如糖尿病、糖尿病并发症、阿尔茨海默病、神经退行性疾病、躁郁症、创伤性脑病、脱发、炎症性疾病、癌症和免疫缺陷。
• COMPOUNDS
  申请人：Baeschlin Daniel Kaspar

  公开号：US20090192138A1

  公开（公告）日：2009-07-30

  The invention provides novel deazaxanthine and deazahypoxanthine compounds. The compounds may be useful in the therapy of diseases and conditions in which dipeptidylpeptidase-IV (DPP-IV) is implicated.

  本发明提供了新型的脱氮黄质和脱氮次黄嘌呤化合物。这些化合物可用于治疗与二肽基肽酶-IV（DPP-IV）有关的疾病和病况。
• PYRROLOPYRIMIDINE DERIVATIVES
  申请人：TEIJIN LIMITED

  公开号：EP1477489A1

  公开（公告）日：2004-11-17

  The invention provides pyrrolo[3,2-d]pyrimidine derivatives represented by formula (I), and their medically acceptable salts. The compounds of the invention exhibit GSK-3 inhibiting activity and are therefore expected to be useful as therapeutic or prophylactic agents for conditions in which GSK-3 is implicated, such as diabetes, diabetes complications, Alzheimer's disease, neurodegenerative diseases, manic depression, traumatic encephalopathy, alopecia, inflammatory diseases, cancer and immune deficiency.

  本发明提供了由式（I）代表的吡咯并[3,2-d]嘧啶衍生物及其医学上可接受的盐类。本发明的化合物具有 GSK-3 抑制活性，因此有望作为治疗或预防药物，用于治疗与 GSK-3 有关的疾病，如糖尿病、糖尿病并发症、阿尔茨海默病、神经退行性疾病、躁狂抑郁症、创伤性脑病、脱发、炎症性疾病、癌症和免疫缺陷。
• US7528140B2
  申请人：——

  公开号：US7528140B2

  公开（公告）日：2009-05-05
• [EN] CONDENSED HETEROCYCLIC COMPOUNDS USEFUL AS DPP-IV INHIBITORS<br/>[FR] COMPOSES HETEROCYCLIQUES CONDENSES UTILES EN TANT QU'INHIBITEURS DE DPP-IV
  申请人：NOVARTIS AG

  公开号：WO2007071738A1

  公开（公告）日：2007-06-28

  [EN] The invention provides novel deazaxanthine and deazahypoxanthine compounds, of formula (I), wherein X is -CH= and Y is =N-; or X is -C(O)- and Y is -N(R³)-; The compounds may be useful in the therapy of diseases and conditions in wich dipeptidylpeptidase-IV (DPP-IV) is implicated.
  [FR] L'invention concerne de nouveaux composés de déazaxanthine et de déazahypoxanthine, de formule (I), dans laquelle X représente -CH= et Y représente =N- ; ou X représente -C(O)- et Y représente -N(R³)-. Ces composés peuvent être utiles pour le traitement de maladies et d'états impliquant la dipeptidylpeptidase-IV (DPP-IV).