Pyrrol-3-carbonsaeuredimethylamid | 60031-39-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: Pyrrol-3-carbonsaeuredimethylamid
• 英文别名: pyrrole-3-carboxylic acid dimethylamide；N,N-dimethyl-1H-pyrrole-3-carboxamide
• CAS: 60031-39-2
• 化学式: C₇H₁₀N₂O
• mdl: MFCD18828716
• 分子量: 138.169
• InChiKey: ZSRDEIIPIQOTNY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.285
• 拓扑面积：
  36.1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• COMPOUNDS AND COMPOSITIONS AS ITPKB INHIBITORS
  申请人：Wan Yongqin

  公开号：US20110263610A1

  公开（公告）日：2011-10-27

  The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated B cell activities, particularly diseases or disorders that involve aberrant activation of inositol 1,4,5-trisphosphate 3-kinase B (ITPKb).

  本发明提供了一类新型化合物，包括含有这些化合物的药物组合物以及使用这些化合物治疗或预防与异常或失调的B细胞活动相关的疾病或障碍的方法，特别是涉及到肌醇1,4,5-三磷酸3-激酶B（ITPKb）异常激活的疾病或障碍。
• Process for production of heteroaryl-type boron compounds with iridium catalyst
  申请人：Miyaura Norio

  公开号：US20050148775A1

  公开（公告）日：2005-07-07

  The present invention provides an economically and industrially superior simple process that enables the selective production of an aromatic heterocyclic monoboron compound and aromatic heterocyclic diboron compound at a satisfactory yield and in a desired ratio by reacting an aromatic heterocyclic compound and a boron compound in a single step under mild conditions while changing only the charged ratios of the raw materials. The present invention provides a production process of a heteroaryl mono- or diboron compound comprising an aromatic heterocyclic compound and a boron compound in the form of bis(pinacolate)diboron or pinacolate diborane in the presence of a iridium-containing catalyst and a ligand such as a bipyridyl ligand.

  本发明提供了一种经济上和工业上优越的简单工艺，通过在温和条件下使芳香杂环化合物和硼化合物进行单步反应，同时仅改变原料的带电比例，就能以满意的产率和所需的比例选择性地生产芳香杂环单硼化合物和芳香杂环二硼化合物。本发明提供了一种杂芳基单硼或二硼化合物的生产工艺，该工艺由芳香杂环化合物和双(频哪醇)二硼或频哪醇二硼烷形式的硼化合物在含铱催化剂和配体如双吡啶配体的存在下组成。
• PROCESS FOR PRODUCTION OF HETEROARYL-TYPE BORON COMPOUNDS WITH IRIDIUM CATALYST
  申请人：MITSUBISHI RAYON CO., LTD.

  公开号：EP1481978B1

  公开（公告）日：2011-09-14
• PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS
  申请人：Exelixis, Inc.

  公开号：EP1773768A2

  公开（公告）日：2007-04-18
• EP1773768A4
  申请人：——

  公开号：EP1773768A4

  公开（公告）日：2008-08-06