2β,4α-diphenylpyrrolidine | 39995-87-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 2β,4α-diphenylpyrrolidine
• 英文别名: (2R,4R)-2,4-diphenylpyrrolidine
• CAS: 39995-87-4；138491-55-1
• 化学式: C₁₆H₁₇N
• 分子量: 223.318
• InChiKey: OKZYNEJPWCDXSG-JKSUJKDBSA-N

物化性质

• 熔点：
  61-63.5 °C
• 沸点：
  155 °C(Press: 1 Torr)
• 密度：
  1.047±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2933990090

反应信息

• 作为产物：
  描述：

  N-甲基苄胺 在 六甲基磷酰三胺 、 N-氯代丁二酰亚胺 、 正丁基锂 、 四甲基乙二胺 、 二异丙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 2.25h， 生成 2β,4α-diphenylpyrrolidine 、 2,3-diphenylpyrrolidine
  参考文献：
  名称：

  Preparation of 2-azaallyl anions and imines from N-chloroamines and their cycloaddition and allylation

  摘要：

  Exposure of N-chloroamines to (KOBu)-Bu-t or LDA, in the presence of PMDETA or HMPA, provides 2-azaallyl anions capable of pi 4s + pi 2s cycloaddition reactions with a range of olefins. Good yields were achieved with stabilised systems, however, they were more modest when accessing semi-stabilised 2-azaallyl anions. By modifying the reaction conditions, one-pot dehydrochlorination/allylation can also be achieved with a range of N-chloroamines. (C) 2010 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2010.11.142

文献信息

• Pearson, William H.; Szura, Daniel P.; Postich, Michael J., Journal of the American Chemical Society, 1992, vol. 114, # 4, p. 1329 - 1345
  作者：Pearson, William H.、Szura, Daniel P.、Postich, Michael J.

  DOI：——

  日期：——
• Preparation of 2-azaallyl anions and imines from N-chloroamines and their cycloaddition and allylation
  作者：Shveta Pandiancherri、David W. Lupton

  DOI：10.1016/j.tetlet.2010.11.142

  日期：2011.2

  Exposure of N-chloroamines to (KOBu)-Bu-t or LDA, in the presence of PMDETA or HMPA, provides 2-azaallyl anions capable of pi 4s + pi 2s cycloaddition reactions with a range of olefins. Good yields were achieved with stabilised systems, however, they were more modest when accessing semi-stabilised 2-azaallyl anions. By modifying the reaction conditions, one-pot dehydrochlorination/allylation can also be achieved with a range of N-chloroamines. (C) 2010 Published by Elsevier Ltd.