Benzoic acid (1R,2R,3R)-2-[(2S,3R,4S,5R,6R)-4,5-bis-(tert-butyl-diphenyl-silanyloxy)-3-iodo-6-methyl-tetrahydro-pyran-2-yloxy]-3-(tert-butyl-diphenyl-silanyloxy)-1-methyl-pent-4-ynyl ester | 330189-28-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Benzoic acid (1R,2R,3R)-2-[(2S,3R,4S,5R,6R)-4,5-bis-(tert-butyl-diphenyl-silanyloxy)-3-iodo-6-methyl-tetrahydro-pyran-2-yloxy]-3-(tert-butyl-diphenyl-silanyloxy)-1-methyl-pent-4-ynyl ester
• 英文别名: [(2R,3R,4R)-3-[(2S,3R,4S,5R,6R)-4,5-bis[[tert-butyl(diphenyl)silyl]oxy]-3-iodo-6-methyloxan-2-yl]oxy-4-[tert-butyl(diphenyl)silyl]oxyhex-5-yn-2-yl] benzoate
• CAS: 330189-28-1
• 化学式: C₆₇H₇₇IO₇Si₃
• 分子量: 1205.51
• InChiKey: ZXGZFEOVTUXWOE-DXIUMNOFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.63
• 重原子数：
  78
• 可旋转键数：
  22
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  72.4
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  Benzoic acid (1R,2R,3R)-2-[(2S,3R,4S,5R,6R)-4,5-bis-(tert-butyl-diphenyl-silanyloxy)-3-iodo-6-methyl-tetrahydro-pyran-2-yloxy]-3-(tert-butyl-diphenyl-silanyloxy)-1-methyl-pent-4-ynyl ester 在 三乙烯二胺 、 六羰基钨 、 二异丁基氢化铝 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 5.5h， 生成 (2R,3R,4R)-3-[(2S,3R,4S,5R,6R)-4,5-Bis-(tert-butyl-diphenyl-silanyloxy)-3-iodo-6-methyl-tetrahydro-pyran-2-yloxy]-4-(tert-butyl-diphenyl-silanyloxy)-2-methyl-3,4-dihydro-2H-pyran
  参考文献：
  名称：

  Discovery of the tungsten carbonyl-catalyzed endo-selective alkynyl alcohol cycloisomerization reaction: applications to stereoselective syntheses of d-olivose, d-olivose disaccharide substructures of landomycin and mithramycin

  摘要：

  An account of the discovery of the tungsten carbonyl-catalyzed endo-selective cycloisomerization of alkynyl alcohols to dihydropyrans is described. The utility of this new chemical transformation involving tungsten vinylidene catalytic intermediates is demonstrated in stereoselective syntheses of disaccharide substructures 26-28 of the landomycin and mithramycin families of anticancer antibiotics. (C) 2001 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0022-328x(00)00643-4
• 作为产物：
  描述：

  Benzoic acid (1R,2R,3R)-3-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-1-methyl-pent-4-ynyl ester 、 Acetic acid (2S,3R,4S,5R,6R)-4,5-bis-(tert-butyl-diphenyl-silanyloxy)-3-iodo-6-methyl-tetrahydro-pyran-2-yl ester 在 叔丁基二甲硅基三氟甲磺酸酯 作用下， 以 二氯甲烷 为溶剂， 反应 1.5h， 以83%的产率得到Benzoic acid (1R,2R,3R)-2-[(2S,3R,4S,5R,6R)-4,5-bis-(tert-butyl-diphenyl-silanyloxy)-3-iodo-6-methyl-tetrahydro-pyran-2-yloxy]-3-(tert-butyl-diphenyl-silanyloxy)-1-methyl-pent-4-ynyl ester
  参考文献：
  名称：

  Discovery of the tungsten carbonyl-catalyzed endo-selective alkynyl alcohol cycloisomerization reaction: applications to stereoselective syntheses of d-olivose, d-olivose disaccharide substructures of landomycin and mithramycin

  摘要：

  An account of the discovery of the tungsten carbonyl-catalyzed endo-selective cycloisomerization of alkynyl alcohols to dihydropyrans is described. The utility of this new chemical transformation involving tungsten vinylidene catalytic intermediates is demonstrated in stereoselective syntheses of disaccharide substructures 26-28 of the landomycin and mithramycin families of anticancer antibiotics. (C) 2001 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0022-328x(00)00643-4