3-[(S)-3-Benzyloxycarbonylamino-2-(3-{(S)-3-benzyloxycarbonylamino-2-[3-((S)-3-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-propionylamino)-benzoylamino]-propionylamino}-benzoylamino)-propionylamino]-benzoic acid 2-oxo-2-phenyl-ethyl ester | 226982-42-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-[(S)-3-Benzyloxycarbonylamino-2-(3-{(S)-3-benzyloxycarbonylamino-2-[3-((S)-3-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-propionylamino)-benzoylamino]-propionylamino}-benzoylamino)-propionylamino]-benzoic acid 2-oxo-2-phenyl-ethyl ester
• CAS: 226982-42-9
• 化学式: C₆₇H₆₇N₉O₁₆
• 分子量: 1254.32
• InChiKey: OPRGNWKAHODOCD-JAZQDMDPSA-N

反应信息

• 作为反应物：
  描述：

  3-[(S)-3-Benzyloxycarbonylamino-2-(3-{(S)-3-benzyloxycarbonylamino-2-[3-((S)-3-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-propionylamino)-benzoylamino]-propionylamino}-benzoylamino)-propionylamino]-benzoic acid 2-oxo-2-phenyl-ethyl ester 在 溶剂黄146 、 锌 作用下， 反应 4.0h， 以92%的产率得到3-[(S)-3-Benzyloxycarbonylamino-2-(3-{(S)-3-benzyloxycarbonylamino-2-[3-((S)-3-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-propionylamino)-benzoylamino]-propionylamino}-benzoylamino)-propionylamino]-benzoic acid
  参考文献：
  名称：

  A pseudopeptide platform with side chains addressable for combinatorial applications

  摘要：

  A synthetic pathway is presented to new, functionalized, pseudopeptide molecular platforms with selectively removable protecting groups on their side chains. The platforms are available in gram quantities and are used as core molecules for combinatorial chemistry. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00544-4
• 作为产物：
  描述：

  3-((S)-3-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-propionylamino)-benzoic acid 、 3-{(S)-2-[3-((S)-2-Amino-3-benzyloxycarbonylamino-propionylamino)-benzoylamino]-3-benzyloxycarbonylamino-propionylamino}-benzoic acid 2-oxo-2-phenyl-ethyl ester; compound with trifluoro-acetic acid 在 1-羟基苯并三唑 、 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 、 N,N-二异丙基乙胺 作用下， 以65%的产率得到3-[(S)-3-Benzyloxycarbonylamino-2-(3-{(S)-3-benzyloxycarbonylamino-2-[3-((S)-3-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-propionylamino)-benzoylamino]-propionylamino}-benzoylamino)-propionylamino]-benzoic acid 2-oxo-2-phenyl-ethyl ester
  参考文献：
  名称：

  A pseudopeptide platform with side chains addressable for combinatorial applications

  摘要：

  A synthetic pathway is presented to new, functionalized, pseudopeptide molecular platforms with selectively removable protecting groups on their side chains. The platforms are available in gram quantities and are used as core molecules for combinatorial chemistry. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00544-4