2H,4H-6-bromo-4-hydroxybenzo[b]-1,4-oxazin-3-one | 711023-15-3

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 2H,4H-6-bromo-4-hydroxybenzo[b]-1,4-oxazin-3-one
• 英文别名: 6-bromo-(2H)-1,4-benzoxazin-3(4H)-one；6-Bromo-4-hydroxy-1,4-benzoxazin-3-one
• CAS: 711023-15-3
• 化学式: C₈H₆BrNO₃
• 分子量: 244.045
• InChiKey: KXPCTORNZFIINK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-(4-bromo-2-nitrophenoxy)acetic acid 在 硫酸 作用下， 以 甲醇 、 水 为溶剂， 以73 %的产率得到2H,4H-6-bromo-4-hydroxybenzo[b]-1,4-oxazin-3-one
  参考文献：
  名称：

  通过硝基芳烃还原简单电化学合成环状异羟肟酸

  摘要：

  硝基芳烃的电化学还原允许直接获得多种含氮杂环。这项工作报道了 18 种不同的 2 H ,4 H -4-羟基-1,4-苯并恶嗪-3-酮的简单直接的有机电合成，产率高达 81%。该方法的可扩展性在克级上得到了证明。

  DOI：

  10.1039/d4cc02118e

文献信息

• Benzoxazin-3-ones and derivatives thereof as therapeutic agents
  申请人：——

  公开号：US20040121996A1

  公开（公告）日：2004-06-24

  The present invention provides compounds of Formula I 1 wherein W, Q, E, D, R 6 , R 7 , R 8 , Y, K, R 9 , R 10 , R 12 , G, and the double bond denoted “*” have any of the values defined therefore in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I.

  本发明提供了I式化合物，其中W，Q，E，D，R6，R7，R8，Y，K，R9，R10，R12，G和表示为“*”的双键具有规范中定义的任何值，并且其药学上可接受的盐，可用作治疗疾病和病症的药物，包括炎症性疾病，心血管疾病和癌症。还提供了包含一种或多种I式化合物的制药组合物。
• PHYTOTOXIC HALOGENATED DERIVATIVES OF BENZOXAZINONES
  申请人：Universidad de Cadiz

  公开号：EP2048136A1

  公开（公告）日：2009-04-15

  The invention relates to phytotoxic halogenated derivatives of benzoxazinones. The aim of the invention relates to the production of novel phytosanitary products that are suitable for agricultural weed control, based on natural chemical substances. The invention comprises novel chemical compounds having high levels of phytotoxic activity and the preparation methods thereof. Said substances are derived from natural products with the 1,4-benzoxazin-3-one skeleton involved in different chemical defense interactions in plants. The inventive compounds have suitable phytotoxic activity levels for use in weed control and for use as stable models for the development of novel phytosanitary products based on the 1,4-benzoxazin-3-one skeleton.

  本发明涉及苯并噁嗪酮的植物毒性卤代衍生物。本发明的目的是以天然化学物质为基础，生产适用于农业除草的新型植物检疫产品。本发明包括具有高水平植物毒性活性的新型化合物及其制备方法。所述物质来源于天然产品，其 1,4-苯并恶嗪-3-酮骨架参与植物不同的化学防御相互作用。本发明的化合物具有合适的植物毒性活性水平，可用于杂草控制，并可用作开发基于 1,4-苯并恶嗪-3-酮骨架的新型植物检疫产品的稳定模型。
• BENZOXAZIN-3-ONES AND DERIVATIVES THEREOF AS INHIBITORS OF PI3K
  申请人：Warner-Lambert Company LLC

  公开号：EP1569653A1

  公开（公告）日：2005-09-07
• US7205295B2
  申请人：——

  公开号：US7205295B2

  公开（公告）日：2007-04-17
• [EN] BENZOXAZIN-3-ONES AND DERIVATIVES THEREOF AS INHIBITORS OF PI3K<br/>[FR] BENZOXAZIN-3-ONES ET DERIVES DE CEUX-CI UTILISES EN TANT QU'INHIBITEURS DE PI3K
  申请人：WARNER LAMBERT CO

  公开号：WO2004052373A1

  公开（公告）日：2004-06-24

  The present invention provides compounds of Formula (I) wherein W, Q, E, D, R6, R7, R8, Y, K, R9, R1O, R12, G, and the double bond denoted '*' have any of the values defined therefore in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula (I). The compounds are inhibitors of phosphoinsitide-3-kinase (P13K).