3-benzoylamino-1-(phenylsulfonyl)pyrrole | 1002331-34-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-benzoylamino-1-(phenylsulfonyl)pyrrole
• 英文别名: N-(1-(phenylsulfonyl)-1H-pyrrol-3-yl)benzamide；N-[1-(benzenesulfonyl)pyrrol-3-yl]benzamide
• CAS: 1002331-34-1
• 化学式: C₁₇H₁₄N₂O₃S
• 分子量: 326.376
• InChiKey: OEBOHZLTZXWANQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  76.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  己酸酐 、 3-nitro-1-(phenylsulfonyl)pyrrole 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 以80%的产率得到3-benzoylamino-1-(phenylsulfonyl)pyrrole
  参考文献：
  名称：

  Reductive acylation of 2- and 3-nitropyrroles—efficient syntheses of pyrrolylamides and pyrrolylimides

  摘要：

  An efficient one-pot synthesis of pyrrolylamides and pyrrolylimides is described under mild reaction conditions by the catalytic hydrogenation of 2- and 3-nitropyrroles. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.10.113

文献信息

• MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION
  申请人：Conn P. Jeffrey

  公开号：US20130040944A1

  公开（公告）日：2013-02-14

  Pyrrole compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.

  吡咯类化合物对代谢型谷氨酸受体亚型4(mGluR4)的变构势效增强/正变构调节剂有用；制备该化合物的合成方法；包含该化合物的制药组合物；以及使用该化合物的方法，例如，用于治疗神经和精神障碍或与谷氨酸功能失调有关的其他疾病状态。
• [EN] MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION<br/>[FR] POTENTIALISATEURS ALLOSTÉRIQUES DU MGLUR4, COMPOSITIONS ET MÉTHODES DE TRAITEMENT D'UN DYSFONCTIONNEMENT NEUROLOGIQUE
  申请人：UNIV VANDERBILT

  公开号：WO2011050316A1

  公开（公告）日：2011-04-28

  Pyrrole compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
• Reductive acylation of 2- and 3-nitropyrroles—efficient syntheses of pyrrolylamides and pyrrolylimides
  作者：Liangfeng Fu、Gordon W. Gribble

  DOI：10.1016/j.tetlet.2007.10.113

  日期：2007.12

  An efficient one-pot synthesis of pyrrolylamides and pyrrolylimides is described under mild reaction conditions by the catalytic hydrogenation of 2- and 3-nitropyrroles. (C) 2007 Elsevier Ltd. All rights reserved.