4-hydroxy-3-[4-(3-furyl)phenyl]-5-phenyl-6,7-dihydro-thieno[2,3-b]pyridin-6-one | 1194091-57-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 4-hydroxy-3-[4-(3-furyl)phenyl]-5-phenyl-6,7-dihydro-thieno[2,3-b]pyridin-6-one
• 英文别名: 3-[4-(furan-3-yl)phenyl]-4-hydroxy-5-phenyl-7H-thieno[2,3-b]pyridin-6-one
• CAS: 1194091-57-0
• 化学式: C₂₃H₁₅NO₃S
• 分子量: 385.443
• InChiKey: HTSCUWYKAYZEFP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  90.7
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] THIENOPYRIDONE DERIVATIVES AS AMP-ACTIVATED PROTEIN KINASE (AMPK) ACTIVATORS<br/>[FR] DÉRIVÉS DE THIÉNOPYRIDONE COMME ACTIVATEURS DE LA PROTÉINE KINASE ACTIVÉE PAR L'AMP (AMPK)
  申请人：MERCK PATENT GMBH

  公开号：WO2009135580A1

  公开（公告）日：2009-11-12

  The present invention relates to compounds of formula (I) wherein R1, R2 and B1, B2 are as defined in claim 1, including pharmaceutical compositions thereof and for their use in the treatment and/or prevention of diseases and disorders modulated by AMP agonists. The invention is also directed to intermediates and to a method of preparation of compounds of formula (I).

  本发明涉及公式（I）中的化合物，其中R1、R2和B1、B2如权利要求1所定义，包括其药物组成物，并用于治疗和/或预防由AMP激动剂调节的疾病和紊乱。该发明还涉及中间体和公式（I）化合物的制备方法。
• THIENOPYRIDONE DERIVATIVES AS AMP-ACTIVATED PROTEIN KINASE (AMPK) ACTIVATORS
  申请人：Merck Patent GmbH

  公开号：EP2280952A1

  公开（公告）日：2011-02-09
• THIENOPYRIDONE DERIVATIVES AS AMP- ACTIVATED PROTEIN KINASE (AMPK) ACTIVATORS
  申请人：Cravo Daniel

  公开号：US20110060001A1

  公开（公告）日：2011-03-10

  The present invention relates to compounds of formula (I) wherein R 1 , R 2 and B 1 , B 2 are as defined in claim 1 , including pharmaceutical compositions thereof and for their use in the treatment and/or prevention of diseases and disorders modulated by AMP agonists. The invention is also directed to intermediates and to a method of preparation of compounds of formula (I).
• US8604202B2
  申请人：——

  公开号：US8604202B2

  公开（公告）日：2013-12-10