trans-8((R)-1-phenypropan-2-yloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one | 1308248-05-6

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: trans-8((R)-1-phenypropan-2-yloxy)-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[3,4-c]azepin-6(10bH)-one
• 英文别名: trans-8-((R)-1-phenylpropan-2-yloxy)-1,2,3,3a,4,5-hexahydrobenzo[c]pyrrolo[3,4-e]azepin-6(10bH)-one；8-[(2R)-1-phenylpropan-2-yl]oxy-2,3,3a,4,5,10b-hexahydro-1H-pyrrolo[3,4-d][2]benzazepin-6-one
• CAS: 1308248-05-6
• 化学式: C₂₁H₂₄N₂O₂
• 分子量: 336.434
• InChiKey: OPNVDOGOYSIGSN-PCVOSPCESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  50.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF
  申请人：AbbVie Inc.

  公开号：EP2571353A1

  公开（公告）日：2013-03-27
• [EN] MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF<br/>[FR] MODULATEURS DES RÉCEPTEURS 5-HT ET LEURS PROCÉDÉS D'UTILISATION
  申请人：ABBOTT LAB

  公开号：WO2011146089A1

  公开（公告）日：2011-11-24

  The present application relates to aryl- and heteroaryl-fused decahydropyrroloazepine, octahydrooxepinopyrrole, octahydropyrrolothiazepine dioxide, decahydrocyclohepta[c]pyrrole, and octahydrocyclohepta[c]pyrrole derivatives of formula (I) wherein R1, R2, R3, R4, R5, A, Y1, Y2, and Y3 are as defined in the specification. The present application also relates to compositions comprising such compounds, processes for making such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.