2-hydroxy-6-oxo-hepta-2,4-dienoic acid | 16354-63-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: 2-hydroxy-6-oxo-hepta-2,4-dienoic acid
• 英文别名: 2-Hydroxy-6-oxo-hepta-2t,4t-diensaeure；2,4-Heptadienoic acid, 2-hydroxy-6-oxo-；(2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoic acid
• CAS: 16354-63-5
• 化学式: C₇H₈O₄
• 分子量: 156.138
• InChiKey: HVZGWILTESYJSP-ZPYFUIHZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Method for the Production of Glutaconate
  申请人：Zelder Oskar

  公开号：US20120021472A1

  公开（公告）日：2012-01-26

  The present invention relates to a novel method for the biocatalytic production of unsaturated dicarboxylic acids by cultivating a recombinant microorganism co-expressing a glutaconate CoA-transferase and a 2-hydroxyglutaryl-CoA dehydratase system. The present invention also relates to corresponding recombinant hosts, recombinant vectors, expression cassettes and nucleic acids suitable for preparing such hosts as well as a method of preparing polyamide or polyester copolymers making use of said dicarboxylic acids as obtained by said biocatalytic production method.

  本发明涉及一种新的生物催化生产不饱和二羧酸的方法，通过培养重组微生物共同表达谷氨酸辅酶A转移酶和2-羟基戊二酰辅酶A脱水酶系统。本发明还涉及相应的重组宿主、重组载体、表达载体和适用于制备此类宿主的核酸，以及利用所述生物催化生产方法所获得的该二羧酸制备聚酰胺或聚酯共聚物的方法。
• Construction of novel mutant micro-organisms
  申请人：CELGENE CORPORATION

  公开号：EP0138391A1

  公开（公告）日：1985-04-24

  This invention provides novel mutant strains of microorganisms (e.g., Pseudomonas putida Biotype A) which are capable of converting substrates such as toluene, p-xylene, catechol' and 4-methylcatechol to 2-hydroxymuconic semialdehyde or substituted analogue of 2-hydroxymuconic semialdehyde quantitatively by the meta (catechol 2,3-oxygenase) pathway. No active 2-hydroxymuconic semialdehyde-metabolising enzymes are induced in the micro-organism, thereby permitting a 2-hydroxymuconic semialdehyde type metabolite to be produced and accumulated in a bioconversion medium containing the micro-organism.

  本发明提供了新型微生物突变菌株（如 Pseudomonas putida Biotype A），它们能够通过 meta（儿茶酚 2,3-加氧酶）途径将甲苯、对二甲苯、邻苯二酚和 4-甲基邻苯二酚等底物定量转化为 2-羟基木酮缩甲醛或 2-羟基木酮缩甲醛的替代类似物。 在微生物中不诱导活性 2-羟基木酮半甲醛代谢酶，从而允许 2-羟基木酮半甲醛类型的代谢物在含有该微生物的生物转化培养基中产生和积累。
• Mutant microorganismexpressing oxygenase, processes of degrading organic compounds and remediation of the environment, using it
  申请人：CANON KABUSHIKI KAISHA

  公开号：EP0730027A2

  公开（公告）日：1996-09-04

  A mutant microorganism capable of degrading organic compounds without any inducer,    wherein the microorganism expresses oxygenase constitutively, and is a mutant derived from a parent microorganism capable of expressing an oxygenase enzyme with an inducer, by mutagenization using a mutagen, and a process for degrading organic compounds and remedying environment using the microorganism, as well as a process for detecting a microorganism constitutively expressing oxygenase among oxygenase-inducible microorganisms.

  一种能够在不使用任何诱导剂的情况下降解有机化合物的突变微生物、 其中，该微生物组成型地表达氧合酶，并且是通过使用诱变剂进行诱变，从能够表达氧合酶的母体微生物中衍生出来的突变体，以及使用该微生物降解有机化合物和修复环境的工艺，以及在氧合酶诱导型微生物中检测组成型表达氧合酶的微生物的工艺。
• Probe compound for detecting and isolating enzymes and means and methods using the same
  申请人：Helmholtz-Zentrum für Infektionsforschung GmbH

  公开号：EP2230312A1

  公开（公告）日：2010-09-22

  The present invention relates to a probe compound that can comprise any substrate or metabolite of an enzymatic reaction in addition to an indicator component, such as, for example, a fluorescence dye, or the like. Moreover, the present invention relates to means for detecting enzymes in form of an array, which comprises any number of probe compounds of the invention which each comprise a different metabolite of interconnected metabolites representing the central pathways in all forms of life. Moreover, the present invention relates to a method for detecting enzymes involving the application of cell extracts or the like to the array of the invention which leads to reproducible enzymatic reactions with the substrates. These specific enzymatic reactions trigger the indicator (e.g. a fluorescence signal) and bind the enzymes to the respective cognate substrates. Moreover, the invention relates to means for isolating enzymes in form of nanoparticles coated with the probe compound of the invention. The immobilisation of the cognate substrates or metabolites on the surface of nanoparticles by means of the probe compounds allows capturing and isolating the respective enzyme, e.g. for subsequent sequencing.

  本发明涉及一种探针化合物，它可以包括酶反应的任何底物或代谢物，此外还包括指示成分，例如荧光染料或类似物。此外，本发明还涉及以阵列形式检测酶的方法，该阵列由任意数量的本发明探针化合物组成，每种探针化合物由代表所有生命形式中中心途径的相互关联的代谢物中的不同代谢物组成。此外，本发明还涉及一种检测酶的方法，该方法涉及将细胞提取物或类似物应用于本发明的阵列，从而导致与底物发生可重复的酶反应。这些特定的酶反应会触发指示剂（如荧光信号），并将酶与各自的同源底物结合。此外，本发明还涉及以涂覆有本发明探针化合物的纳米颗粒形式分离酶的方法。通过探针化合物将同源底物或代谢物固定在纳米颗粒表面，可以捕获和分离相应的酶，例如用于后续测序。
• Novel polynucleotides
  申请人：Nakagawa Satoshi

  公开号：US20060228712A1

  公开（公告）日：2006-10-12

  Novel polynucleotides derived from microorganisms belonging to coryneform bacteria and fragments thereof, polypeptides encoded by the polynucleotides and fragments thereof, polynucleotide arrays comprising the polynucleotides and fragments thereof, recording media in which the nucleotide sequences of the polynucleotide and fragments thereof have been recorded which are readable in a computer, and use of them.

  从属于冠状病毒细菌的微生物中提取的新型多核苷酸及其片段、由多核苷酸及其片段编码的多肽、包含多核苷酸及其片段的多核苷酸阵列、记录了多核苷酸及其片段的核苷酸序列且可在计算机中读取的记录介质，以及它们的用途。