(2S,3aS,7aS)-1-[(2S)-2-[[(2R)-1-ethoxy-1-oxopentan-2-yl]azaniumyl]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S,3aS,7aS)-1-[(2S)-2-[[(2R)-1-ethoxy-1-oxopentan-2-yl]azaniumyl]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylate
• 化学式: C19H32N2O5
• 分子量: 368.5
• InChiKey: IPVQLZZIHOAWMC-QMHWVQJVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.84
• 拓扑面积：
  95.9
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• NOVEL METOD FOR THE SYNTHESIS OF PERINDOPRIL AND THE PHARMACEUTICALLY-ACCEPTABLE SALTS THEREOF
  申请人：Dubuffet Thierry

  公开号：US20070043103A1

  公开（公告）日：2007-02-22

  A process for the synthesis of perindopril of formula (I): and its pharmaceutically acceptable salts.

  一种合成公式(I)的贝那普利及其药用盐的过程。
• NOVEL POLYMORPHIC FORMS OF PERINDOPRIL (L)-ARGININE AND PROCESS FOR THE PREPARATION THEREOF
  申请人：Jetti Ramakoteswara Rao

  公开号：US20110301357A1

  公开（公告）日：2011-12-08

  The present invention relates to novel and stable polymorphic forms of Perindopril (L)-Arginine designated as Form γ and amorphous form and processes for their preparation. The present invention also provides the novel polymorph Form γ with greater stability to heat and humidity and can be prepared on large scale by an efficient, economic and reproducible process.

  本发明涉及一种新型和稳定的普利多巴(L)-精氨酸的多晶型形式，被称为γ型和无定形形式，以及它们的制备过程。本发明还提供了新型的多晶形式γ，具有更好的热和湿度稳定性，可以通过高效、经济和可重复的过程进行大规模制备。
• SALTS OF PERINDOPRIL
  申请人：Merslavic Marjo

  公开号：US20100298400A1

  公开（公告）日：2010-11-25

  The present invention relates to new salts of perindopril, particularly to a new calcium salt and new amine salts of perindopril, to a process for their preparation and to a pharmaceutical formulations containing the new salts.

  本发明涉及新的贝那普利盐，尤其是新的贝那普利钙盐和新的贝那普利胺盐，以及其制备过程和含有新盐的制药配方。
• PERINDOPRIL FORMULATIONS
  申请人：Subramony Janardhanan Anand

  公开号：US20100076052A1

  公开（公告）日：2010-03-25

  Pharmaceutical formulations comprising perindopril or its salts, isomers, enantiomers, polymorphs, metabolites, solvates, hydrates, and mixtures thereof, and at least one surface stabilizer. Also disclosed are methods of stabilizing perindopril in the formulations, and polyoxyethylene-polyoxypropylene block copolymers as surface stabilizers.
• US7157484B2
  申请人：——

  公开号：US7157484B2

  公开（公告）日：2007-01-02