3-hydroxy-3,4-dimethyl-hexanoic acid tert-butyl ester | 5292-14-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-hydroxy-3,4-dimethyl-hexanoic acid tert-butyl ester
• 英文别名: 3-Hydroxy-3,4-dimethyl-hexansaeure-tert-butylester
• CAS: 5292-14-8
• 化学式: C₁₂H₂₄O₃
• 分子量: 216.321
• InChiKey: IRTXNYJCTZWQPL-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  3-hydroxy-3,4-dimethyl-hexanoic acid tert-butyl ester 在 1,4-二氧六环 、 盐酸 作用下， 生成 3-hydroxy-3,4-dimethyl-hexanoic acid
  参考文献：
  名称：

  Selenium Regulates Expression in Rat Liver of Genes for Proteins Involved in Iron Metabolism

  摘要：

  Suppression subtractive hybridization analysis in our laboratory recently revealed that transferrin mRNA may be elevated in Se-deficient rat liver. In this work, we compared expression in rat liver of genes for transferrin, transferrin receptor, ferritin light and heavy chains, and iron-regulatory proteins 1 and 2 in Se adequacy and deficiency. Weanling male Sprague-Dawley rats were fed Torula yeast diets supplemented with 0 or 0.15 mu g Se/kg diet as sodium selenite for 15 wk. Activity of cellular glutathione peroxidase was virtually abolished in Se-deficient rat liver, whereas activity of glutathione S-transferase was 43% higher than in Se-adequate liver. There were no differences in hematocrit, hemoglobin, or liver iron content. To examine differential gene expression, we used a multiplex relative reverse transcriptase-polymerase chain reaction method. Three of the six genes examined showed modest but consistent upregulation in Se deficiency. Transferrin mRNA was 30% more abundant in Se-deficient than in Se-adequate liver. For the transferrin receptor, the difference was 32%, and for iron regulatory protein 1, it was 63%. No consistent differences were observed for iron regulatory protein 2 or for ferritin light or heavy chain. These findings suggest a possible role for dietary Se in moderating iron metabolism.

  DOI：

  10.1385/bter:74:1:55
• 作为产物：
  描述：

  醋酸叔丁酯 、 异丙基氯化镁 在 乙醚 作用下， 生成 3-hydroxy-3,4-dimethyl-hexanoic acid tert-butyl ester
  参考文献：
  名称：

  Selenium Regulates Expression in Rat Liver of Genes for Proteins Involved in Iron Metabolism

  摘要：

  Suppression subtractive hybridization analysis in our laboratory recently revealed that transferrin mRNA may be elevated in Se-deficient rat liver. In this work, we compared expression in rat liver of genes for transferrin, transferrin receptor, ferritin light and heavy chains, and iron-regulatory proteins 1 and 2 in Se adequacy and deficiency. Weanling male Sprague-Dawley rats were fed Torula yeast diets supplemented with 0 or 0.15 mu g Se/kg diet as sodium selenite for 15 wk. Activity of cellular glutathione peroxidase was virtually abolished in Se-deficient rat liver, whereas activity of glutathione S-transferase was 43% higher than in Se-adequate liver. There were no differences in hematocrit, hemoglobin, or liver iron content. To examine differential gene expression, we used a multiplex relative reverse transcriptase-polymerase chain reaction method. Three of the six genes examined showed modest but consistent upregulation in Se deficiency. Transferrin mRNA was 30% more abundant in Se-deficient than in Se-adequate liver. For the transferrin receptor, the difference was 32%, and for iron regulatory protein 1, it was 63%. No consistent differences were observed for iron regulatory protein 2 or for ferritin light or heavy chain. These findings suggest a possible role for dietary Se in moderating iron metabolism.

  DOI：

  10.1385/bter:74:1:55