tert-butyl N2-(((6-bromo-7-hydroxy-2-oxo-2H-chromen-4-yl)methoxy)carbonyl)-N6-(tert-butoxycarbonyl)-L-lysinate | 1207325-82-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tert-butyl N2-(((6-bromo-7-hydroxy-2-oxo-2H-chromen-4-yl)methoxy)carbonyl)-N6-(tert-butoxycarbonyl)-L-lysinate
• CAS: 1207325-82-3
• 化学式: C₂₆H₃₅BrN₂O₉
• 分子量: 599.476
• InChiKey: MBIWJBAIYXYBRN-SFHVURJKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.89
• 重原子数：
  38.0
• 可旋转键数：
  9.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  153.4
• 氢给体数：
  3.0
• 氢受体数：
  9.0

反应信息

• 作为反应物：
  描述：

  tert-butyl N2-(((6-bromo-7-hydroxy-2-oxo-2H-chromen-4-yl)methoxy)carbonyl)-N6-(tert-butoxycarbonyl)-L-lysinate 、 十八烷酰氯 在 三乙胺 作用下， 以 氯仿 为溶剂， 以55%的产率得到(S)-6-bromo-4-(5-(tert-butoxycarbonyl)-13,13-dimethyl-3,11-dioxo-2,12-dioxa-4,10-diazatetradecyl)-2-oxo-2H-chromen-7-yl stearate
  参考文献：
  名称：

  Light-mediated and H-bond facilitated liposomal release: the role of lipid head groups in release efficiency

  摘要：

  Syntheses of coumarin-containing lipids and liposomal formulations incorporating these lipids are studied. The influence of the lipid head groups in enhancing the release efficiency of these liposomes under light irradiation is studied and a molecular mechanism is provided. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.11.084
• 作为产物：
  描述：

  对硝基苯基氯甲酸酯 、 1,1-dimethylethyl N6-{[(1,1-dimethylethyl)oxy]carbonyl}-L-lysinate hydrochloride 、 6-溴-7-羟基-4-(羟甲基)香豆素 在 4-二甲氨基吡啶 作用下， 以 乙腈 为溶剂， 反应 43.0h， 以57%的产率得到tert-butyl N2-(((6-bromo-7-hydroxy-2-oxo-2H-chromen-4-yl)methoxy)carbonyl)-N6-(tert-butoxycarbonyl)-L-lysinate
  参考文献：
  名称：

  Light-mediated and H-bond facilitated liposomal release: the role of lipid head groups in release efficiency

  摘要：

  Syntheses of coumarin-containing lipids and liposomal formulations incorporating these lipids are studied. The influence of the lipid head groups in enhancing the release efficiency of these liposomes under light irradiation is studied and a molecular mechanism is provided. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.11.084