羧甲基-苯丙氨酰-亮氨酸 | 81109-85-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 羧甲基-苯丙氨酰-亮氨酸
• 英文名称: N-(carboxy-methyl)L.phenylalanine-L.leucine
• 英文别名: carboxymethyl-phenylalanine-leucine；L-Leucine,N-(carboxymethyl)-L-phenylalanyl-；(2S)-2-amino-4-methylpentanoic acid;(2S)-2-(carboxymethylamino)-3-phenylpropanoic acid
• CAS: 81109-85-5
• 化学式: C₆H₁₃NO₂*C₁₁H₁₃NO₄
• 分子量: 354.403
• InChiKey: JZJXIRJMLZJQIF-LMECJBHSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  25
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  150
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• Oral drug delivery compositions and methods
  申请人：Emisphere Technologies, Inc.

  公开号：US20030012817A1

  公开（公告）日：2003-01-16

  The present invention relates to an oral drug delivery system, and in particular to modified amino acids and modified amino acid derivatives for use as a delivery system of sensitive agents such as bioactive peptides. The modified amino acids and derivatives can form non-covalent mixtures with active biological agents and in an alternate embodiment can releasably carry active agents. Modified amino acids can also form drug containing microspheres. These mixtures are suitable for oral administration of biologically active agents to animals. Methods for the preparation of such amino acids are also disclosed.

  本发明涉及一种口服药物输送系统，具体涉及用于作为敏感剂的生物活性肽的传递系统的修饰氨基酸和修饰氨基酸衍生物。修饰氨基酸和衍生物可以与活性生物制剂形成非共价混合物，并且在另一实施例中可以释放携带活性剂。修饰氨基酸还可以形成含药微球。这些混合物适用于将生物活性剂口服给动物。还公开了制备这种氨基酸的方法。
• Oral drug compositions and methods
  申请人：Emisphere Technologies, Inc.

  公开号：EP1025840A2

  公开（公告）日：2000-08-09

  The present invention relates to an oral drug delivery system, and in particular to modified amino acids and modified amino acid derivatives for use as a delivery system of sensitive agents such as bioactive peptides. The modified amino acids and derivatives can form non-covalent mixtures with active biological agents and in an alternate embodiment can releasably carry active agents. Modified amino acids can also form durg containing microspheres. These mixtures are suitable for oral administration of biologically active agents to animals. Methods for the preparation of such amino acids are also disclosed.

  本发明涉及一种口服给药系统，特别是用作生物活性肽等敏感制剂给药系统的改性氨基酸和改性氨基酸衍生物。改性氨基酸及其衍生物可与活性生物制剂形成非共价混合物，在另一个实施方案中可释放携带活性制剂。改性氨基酸还可以形成含有微球的杜克。这些混合物适用于给动物口服生物活性剂。还公开了制备此类氨基酸的方法。
• Oral drug delivery compositions
  申请人：Emisphere Technologies, Inc.

  公开号：EP1077070A2

  公开（公告）日：2001-02-21

  The present invention relates to an oral drug delivery system, and in particular to modified amino acids and modified amino acid derivatives for use as a delivery system of sensitive agents such as bioactive peptides. The modified amino acids and derivatives can form non-covalent mixtures with active biological agents and in an alternate embodiment can releasably carry active agents. Modified amino acids can also form durg containing microspheres. These mixtures are suitable for oral administration of biologically active agents to animals. Methods for the preparation of such amino acids are also disclosed.

  本发明涉及一种口服给药系统，特别是用作生物活性肽等敏感制剂给药系统的改性氨基酸和改性氨基酸衍生物。改性氨基酸及其衍生物可与活性生物制剂形成非共价混合物，在另一个实施方案中可释放携带活性制剂。改性氨基酸还可以形成含有微球的杜克。这些混合物适用于给动物口服生物活性剂。还公开了制备此类氨基酸的方法。
• ORAL DRUG DELIVERY COMPOSITIONS AND METHODS
  申请人：Emisphere Technologies, Inc.

  公开号：EP0696208A1

  公开（公告）日：1996-02-14
• EP0696208A4
  申请人：——

  公开号：EP0696208A4

  公开（公告）日：1997-01-29