dTDP-beta-L-rhodinose | 1020266-84-5

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷酸
• 英文名称: dTDP-beta-L-rhodinose
• 英文别名: [hydroxy-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl] [(2R,5S,6S)-5-hydroxy-6-methyloxan-2-yl] hydrogen phosphate
• CAS: 1020266-84-5
• 化学式: C₁₆H₂₆N₂O₁₃P₂
• 分子量: 516.336
• InChiKey: ANSAJFYVUGUZQP-QEHJDLSMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.8
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  211
• 氢给体数：
  5
• 氢受体数：
  13

反应信息

• 作为产物：
  描述：

  [(2S,3S)-6-[hydroxy-[hydroxy-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl]oxyphosphoryl]oxy-2-methyloxan-3-yl] acetate 在 sodium methylate 、 碳酸氢铵 作用下， 以 甲醇 为溶剂， 反应 24.0h， 以20%的产率得到[hydroxy-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl] [(2S,5S,6S)-5-hydroxy-6-methyloxan-2-yl] hydrogen phosphate
  参考文献：
  名称：

  2,3,6-Trideoxy sugar nucleotides: synthesis and stability

  摘要：

  The synthesis and characterization of highly challenging 2,3,6-trideoxy sugar nucleotides were described for the first time. The study of their hydrolysis kinetics in aqueous buffers provided insight into their application as glycosyl donors. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.08.132