(R)-1,1'-bis(diphenylphosphino)-9,9'-spirobifluorene | 866397-47-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-1,1'-bis(diphenylphosphino)-9,9'-spirobifluorene
• 英文别名: (R)-C((C6H4)(C6H3P(C6H5)2))2；(1'-Diphenylphosphanyl-9,9'-spirobi[fluorene]-1-yl)-diphenylphosphane
• CAS: 866397-47-9
• 化学式: C₄₉H₃₄P₂
• 分子量: 684.756
• InChiKey: PFPBWQDHSKARDH-UHFFFAOYSA-N

物化性质

• 熔点：
  325-327 °C

计算性质

• 辛醇/水分配系数(LogP)：
  11.7
• 重原子数：
  51
• 可旋转键数：
  6
• 环数：
  10.0
• sp3杂化的碳原子比例：
  0.02
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  (R)-1,1'-bis(diphenylphosphino)-9,9'-spirobifluorene 、 [RuCl2(benzene)]2 、 sodium acetate 以 N,N-二甲基甲酰胺 为溶剂， 生成 [Ru(OAc)2((R)-C((C6H4)(C6H3P(C6H5)2))2)]
  参考文献：
  名称：

  基于手性螺二芴骨架，具有大二面角的高刚性二膦配体。

  摘要：

  DOI：

  10.1002/anie.200462072
• 作为产物：
  描述：

  1,1'-dihydroxy-9,9'-spirobifluorene 在 吡啶 、 三氯硅烷 、 palladium diacetate 、 N,N-二异丙基乙胺 、 1,4-双(二苯基膦)丁烷 作用下， 以 二氯甲烷 、 二甲基亚砜 、 甲苯 为溶剂， 反应 56.0h， 生成 (R)-1,1'-bis(diphenylphosphino)-9,9'-spirobifluorene
  参考文献：
  名称：

  基于手性螺二芴骨架，具有大二面角的高刚性二膦配体。

  摘要：

  DOI：

  10.1002/anie.200462072

文献信息

• Compound of 3,3,3′,3′-tetramethyl-1,1′-spirobiindane-based phosphine ligand, and preparation method thereof
  申请人：ZHEJIANG UNIVERSITY

  公开号：US11530230B2

  公开（公告）日：2022-12-20

  The present application discloses a 3,3,3′,3′-tetramethyl-1,1′-spirobiindane-based phosphine ligand, an intermediate, a preparation method and uses thereof. The compound of phosphine ligand is a compound having a structure represented by formula I or formula II, or an enantiomer, a raceme, or diastereomer thereof. The phosphine ligand can be prepared via a preparation scheme in which the cheap and easily available 6,6′-dihydroxyl-3,3,3′,3′-tetramethyl-1,1′-spirobiindane is used as a raw material and the compound represented by formula III serves as the key intermediate. The new phosphine ligand developed by the present application can be used in catalytic organic reaction, in particular as a chiral phosphine ligand that is widely used in many asymmetric catalytic reactions including asymmetric hydrogenation and asymmetric allyl alkylation, and thus it has economic practicability and industrial application prospect.

  本申请公开了一种 3,3,3′,3′-四甲基-1,1′-螺双茚满基膦配体、中间体、制备方法及其用途。膦配体化合物是具有式 I 或式 II 所代表结构的化合物，或其对映体、外消旋体或非对映异构体。膦配体可以通过一种制备方案来制备，在该方案中，廉价易得的 6,6′-二羟基-3,3,3′,3′-四甲基-1,1′-螺生物茚满用作原料，式 III 所代表的化合物用作关键中间体。本申请开发的新型膦配体可用于催化有机反应，特别是作为手性膦配体广泛应用于不对称氢化、不对称烯丙基烷基化等多种不对称催化反应，具有经济实用性和工业应用前景。
• COMPOUND OF 3,3,3',3'-TETRAMETHYL-1,1'-SPIROBIINDANE-BASED PHOSPHINE LIGAND, AND PREPARATION METHOD THEREOF
  申请人：ZHEJIANG UNIVERSITY

  公开号：US20210163514A1

  公开（公告）日：2021-06-03

  The present application discloses a 3,3,3′,3′-tetramethyl-1,1′-spirobiindane-based phosphine ligand, an intermediate, a preparation method and uses thereof. The compound of phosphine ligand is a compound having a structure represented by formula I or formula II, or an enantiomer, a raceme, or diastereomer thereof. The phosphine ligand can be prepared via a preparation scheme in which the cheap and easily available 6,6′-dihydroxyl-3,3,3′,3′-tetramethyl-1,1′-spirobiindane is used as a raw material and the compound represented by formula III serves as the key intermediate. The new phosphine ligand developed by the present application can be used in catalytic organic reaction, in particular as a chiral phosphine ligand that is widely used in many asymmetric catalytic reactions including asymmetric hydrogenation and asymmetric allyl alkylation, and thus it has economic practicability and industrial application prospect.