The present invention relates to novel oxazolidinone derivatives with cyclic amidines, and prodrugs, hydrates, solvates, isomers and pharmaceutically acceptable salts thereof, and processes for preparing the same, and pharmaceutical compositions comprising the same. The oxazolidinone derivatives with cyclic amidines, and prodrugs, hydrates, solvates, isomers and pharmaceutically acceptable salts thereof can be usefully employed as an anticoagulant for treating thromboembolism and tumors via inhibition of coagulation factor Xa.
本发明涉及具有环状酰胺的新型
噁唑啉酮衍
生物及其前药、
水合物、溶剂合物、异构体和药学上可接受的盐,以及制备它们的过程和包含它们的药物组合物。具有环状酰胺的
噁唑啉酮衍
生物及其前药、
水合物、溶剂合物、异构体和药学上可接受的盐可用作抗凝剂,通过抑制
凝血因子Xa治疗血栓栓塞和肿瘤。