(4R,5R)-N,N'-Bis-((R)-1-phenyl-ethyl)-octa-1,7-diene-4,5-diamine | 138767-30-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (4R,5R)-N,N'-Bis-((R)-1-phenyl-ethyl)-octa-1,7-diene-4,5-diamine
• 英文别名: (4R,5R)-4-N,5-N-bis[(1R)-1-phenylethyl]octa-1,7-diene-4,5-diamine
• CAS: 138767-30-3
• 化学式: C₂₄H₃₂N₂
• 分子量: 348.531
• InChiKey: ATZFBNIGZKFWRG-FAYOUJPWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  26
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (4R,5R)-N,N'-Bis-((R)-1-phenyl-ethyl)-octa-1,7-diene-4,5-diamine 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 生成 (4R,5R)-辛烷-4,5-二胺
  参考文献：
  名称：

  The stereoselective synthesis of functionalized vicinal diamine systems by the double allylation reactions of “protected” 1,2-bis-imine precursors.

  摘要：

  A diastereoselective synthesis of vicinal diamines via the reactions of allylic Grignard reagents with readily available "protected" 1,2-bisimines has been developed. This method has been extended to preparing optically pure diamines by the use of chiral 1,2-bisimine precursors.

  DOI：

  10.1016/s0040-4039(00)79412-3
• 作为产物：
  描述：

  氯丙烯镁 、 Benzenemethanamine, N,N'-1,2-ethanediylidenebis[α-methyl-, [N(E),N'(E),αR,α'R]-rel- 以 四氢呋喃 为溶剂， 生成 N,N'-bis((R)-1-phenylethyl)-(S,S)-4,5-diamine-1,7-octadiene 、 (4R,5R)-N,N'-Bis-((R)-1-phenyl-ethyl)-octa-1,7-diene-4,5-diamine
  参考文献：
  名称：

  The stereoselective synthesis of functionalized vicinal diamine systems by the double allylation reactions of “protected” 1,2-bis-imine precursors.

  摘要：

  A diastereoselective synthesis of vicinal diamines via the reactions of allylic Grignard reagents with readily available "protected" 1,2-bisimines has been developed. This method has been extended to preparing optically pure diamines by the use of chiral 1,2-bisimine precursors.

  DOI：

  10.1016/s0040-4039(00)79412-3

文献信息

• The stereoselective synthesis of functionalized vicinal diamine systems by the double allylation reactions of “protected” 1,2-bis-imine precursors.
  作者：William L. Neumann、Milorad M. Rogic、T.Jeffrey Dunn

  DOI：10.1016/s0040-4039(00)79412-3

  日期：1991.10

  A diastereoselective synthesis of vicinal diamines via the reactions of allylic Grignard reagents with readily available "protected" 1,2-bisimines has been developed. This method has been extended to preparing optically pure diamines by the use of chiral 1,2-bisimine precursors.