Einecs 285-802-0 | 85153-23-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Einecs 285-802-0
• 英文别名: (2S)-2,6-diaminohexanoic acid;5-oxopyrrolidine-2-carboxylic acid
• CAS: 85153-23-7
• 化学式: C11H21N3O5
• 分子量: 275.3
• InChiKey: GSTSUZHIVMCRLR-JEDNCBNOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.12
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  156
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• [EN] ACTIVE INGREDIENT COMPRISING A MIXTURE OF UNSATURATED DICARBOXYLIC FATTY ACIDS, COMPOSITIONS COMPRISING SAID INGREDIENT AND COSMETIC OR DERMATOLOGICAL USES<br/>[FR] PRINCIPE ACTIF COMPRENANT UN MÉLANGE D'ACIDES GRAS DICARBOXYLIQUES INSATURÉS, COMPOSITIONS COMPRENANT LEDIT PRINCIPE, ET UTILISATIONS COSMÉTIQUES OU DERMATOLOGIQUES
  申请人：SEDERMA SA

  公开号：WO2016012973A1

  公开（公告）日：2016-01-28

  The ingredient comprises a mixture of unsaturated dicarboxylic acids comprising the Z and E isomers of at least one mono-unsaturated dicarboxylic C12-C24 acid, the concentration of the E isomer being of at least 25% by weight based on the total weight of Z and E isomers The ingredient can be used to form cosmetic or dermatological compositions, in particular for lightening the skin, improving the clarity and unification of the skin complexion.80

  该成分包含一种不饱和二羧酸混合物，包括至少一种单不饱和二羧酸C12-C24酸的Z和E异构体，其中E异构体的浓度至少为总Z和E异构体重量的25%。该成分可用于制备化妆品或皮肤科学配方，特别是用于美白皮肤，改善皮肤肤色的清晰度和统一性。
• Administration of dithiolane compounds for photoprotecting the skin
  申请人：Marat Xavier

  公开号：US20100197759A1

  公开（公告）日：2010-08-05

  Dithiolane compounds having the structural formula (I): are useful for reinforcing and/or preserving the natural antioxidant protection of the skin against oxidative stress caused, especially, by UV radiation, e.g., by increasing the level of intracellular glutathione.

  具有结构式（I）的二硫杂环化合物对于增强和/或保护皮肤的天然抗氧化保护作用非常有用，特别是对抗氧化应激，例如紫外辐射引起的应激，例如通过增加细胞内谷胱甘肽的水平。
• [EN] DITHIOLANE COMPOUNDS; COMPOSITIONS CONTAINING THEM; USES FOR PHOTOPROTECTING THE SKIN<br/>[FR] COMPOSÉS DE DITHIOLANE ; COMPOSITIONS LES CONTENANT, LEURS UTILISATIONS POUR LA PHOTOPROTECTION DE LA PEAU
  申请人：OREAL

  公开号：WO2010040603A1

  公开（公告）日：2010-04-15

  The present invention relates to novel dithiolane compounds of formula (I) below: formula (I), in which Y denotes 0, NR1 or S; R1 denotes a hydrogen atom; a saturated linear C1-C20 or branched C3-C20 or unsaturated C2-C20 alkyl hydrocarbon- based group; an aryl group optionally substituted with one or more hydroxyls and/or with one or more C1-C8 alkoxy radicals; R denotes a hydrogen atom; a saturated linear C1-C20 or branched C3-C20 or unsaturated C2-C20 alkyl hydrocarbon- based group; a radical having the following formula (Ia), in which n = 0, 1, 2, 3 or 4; x = 0, 1, 2 or 3 and R3, which may be identical or different, denote a hydrogen atom or a linear or branched C1-C4 alkyl such as methyl, ethyl or isopropyl; the radical 4-methyl dithiolane when Y denotes NH; when Y denotes NHR1 and R1 is other than hydrogen, R and Ri may form a ring. The invention also relates to the uses of these compounds for reinforcing the natural antioxidant protection of the skin against oxidative stress caused especially by UV radiation.

  本发明涉及以下式子（I）的新型二硫杂环化合物：式子（I），其中Y表示0、NR1或S；R1表示氢原子；基于饱和线性C1-C20或支链C3-C20或不饱和C2-C20烷基碳的基团；一种芳基，可选地带有一个或多个羟基和/或一个或多个C1-C8烷氧基；R表示氢原子；基于饱和线性C1-C20或支链C3-C20或不饱和C2-C20烷基碳的基团；一种具有以下式子（Ia）的基团，其中n = 0,1,2,3或4；x = 0,1,2或3，R3可能相同也可能不同，表示氢原子或线性或支链C1-C4烷基，如甲基、乙基或异丙基；当Y表示NH时，基团为4-甲基二硫杂环；当Y表示NHR1且R1不是氢时，R和Ri可以形成环。本发明还涉及这些化合物用于增强皮肤对氧化应激（尤其是紫外线辐射引起的）的天然抗氧化保护的用途。
• Peptides for skin rejuvenation and methods of using the same
  申请人：Anteis SA

  公开号：US10543195B2

  公开（公告）日：2020-01-28

  The invention provides compositions for stimulating the formation of one or more extracellular matrix components that contain a lipoaminoacid derivative of the tripeptide carnosine such as N-Octanoyl Carnosine. Also provided are compositions containing N-Octanoyl Carnosine in combination with selected tripeptide and/or tetrapeptides as well as pharmaceutical and/or cosmetic compositions containing such compositions. The invention further provides methods of using the compositions and compositions of the invention to treat, alleviate, and/or ameliorate a symptom, condition, disorder, or disease of the skin or mucosa, wherein the symptom, condition, disorder, or disease is associated with changes in extracellular matrix components.

  本发明提供了刺激一种或多种细胞外基质成分形成的组合物，这些组合物含有三肽肉碱的脂氨基酸衍生物，如 N-辛酰肉碱。本发明还提供了含有 N-辛酰肉碱与所选三肽和/或四肽的组合物，以及含有此类组合物的药物和/或化妆品组合物。本发明进一步提供了使用本发明的组合物和组合物治疗、减轻和/或改善皮肤或粘膜的症状、状况、失调或疾病的方法，其中症状、状况、失调或疾病与细胞外基质成分的变化有关。
• Compositions containing silymarin and sulfoalkyl ether cyclodextrin and methods of using the same
  申请人：UNIVERSITY OF KANSAS

  公开号：US10702568B2

  公开（公告）日：2020-07-07

  Cosmetic and dietary supplement compositions containing silymarin and sulfoalkyl ether cyclodextrin, particularly sulfobutyl ether cyclodextrin, are described. The compositions and methods are useful in reducing appearance of facial redness in rosacea-prone skin, rejuvenating skin, preventing skin aging, inhibiting oxidative stress in epidermal and dermal cells, increasing collagen production, reducing the likelihood of skin cancer, treating or reducing liver damage from a toxin, or treating a liver disease.

  描述了含有水飞蓟素和磺烷基醚环糊精，特别是磺丁基醚环糊精的化妆品和膳食补充剂组合物。这些组合物和方法可用于减少易患红斑痤疮的皮肤出现面部发红、嫩肤、防止皮肤老化、抑制表皮和真皮细胞中的氧化应激、增加胶原蛋白的生成、减少皮肤癌的可能性、治疗或减少毒素对肝脏的损害或治疗肝病。