Manzamine B | 112663-92-0

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 哈马拉生物碱
• 英文名称: Manzamine B
• 英文别名: (1R,2R,8Z,12R,13S,21Z,26S,27R)-27-(9H-pyrido[3,4-b]indol-1-yl)-25-oxa-3,16-diazapentacyclo[11.11.3.112,16.01,26.02,12]octacosa-8,21-diene
• CAS: 112663-92-0
• 化学式: C₃₆H₄₆N₄O
• 分子量: 550.787
• InChiKey: VLWWSOADVQPMJO-ZOSDTVTQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  41
• 可旋转键数：
  1
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  56.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Manzamine B 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 以3.0 mg的产率得到manzamine J
  参考文献：
  名称：

  Ircinals A and B from the Okinawan marine sponge Ircinia sp.: plausible biogenetic precursors of manzamine alkaloids

  摘要：

  DOI：

  10.1021/jo00034a052
• 作为产物：
  描述：

  (1S)-1,2,3,4-tetrahydromanzamine B 在 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 乙醇 、 氯仿 为溶剂， 反应 1.0h， 以40%的产率得到Manzamine B
  参考文献：
  名称：

  Tsuda, Masashi; Watanabe, Daisuke; Kobayashi, Jun'ichi, Heterocycles, 1999, vol. 50, # 1, p. 485 - 488

  摘要：

  DOI：

文献信息

• Use of manzamine compounds in anti-cancer therapeutic regimens
  申请人：Guzman A. Esther

  公开号：US20070203113A1

  公开（公告）日：2007-08-30

  Manzamine compounds have been discovered to decrease cell dissociation and cell migration associated with the metastatic potential of cancer cells and a restoration of cancer cell susceptibility to agents, such as TRAIL, which can induce apoptosis. Specifically, Manzamine A has a formerly unrecognized utility in both blocking tumor cell invasion and tumor metastasis as well in restoring cancer cell susceptibility to standard chemotherapeutic agents which induce apoptosis and, therefore, has utility in treating cancer.
• Use of Manzamine Compounds in Anti-Cancer Therapeutic Regimens
  申请人：Guzman Esther A.

  公开号：US20120289533A1

  公开（公告）日：2012-11-15

  Manzamine compounds have been discovered to decrease cell dissociation and cell migration associated with the metastatic potential of cancer cells and a restoration of cancer cell susceptibility to agents, such as TRAIL, which can induce apoptosis. Specifically, Manzamine A has a formerly unrecognized utility in both blocking tumor cell invasion and tumor metastasis as well in restoring cancer cell susceptibility to standard chemotherapeutic agents which induce apoptosis and, therefore, has utility in treating cancer.
• US8232266B2
  申请人：——

  公开号：US8232266B2

  公开（公告）日：2012-07-31
• Ircinals A and B from the Okinawan marine sponge Ircinia sp.: plausible biogenetic precursors of manzamine alkaloids
  作者：Kazuhiko Kondo、Hideyuki Shigemori、Yumiko Kikuchi、Masami Ishibashi、Takuma Sasaki、Junichi Kobayashi

  DOI：10.1021/jo00034a052

  日期：1992.4
• Tsuda, Masashi; Watanabe, Daisuke; Kobayashi, Jun'ichi, Heterocycles, 1999, vol. 50, # 1, p. 485 - 488
  作者：Tsuda, Masashi、Watanabe, Daisuke、Kobayashi, Jun'ichi

  DOI：——

  日期：——