Creatine AKG | 315669-78-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Creatine AKG
• 英文别名: 2-[carbamimidoyl(methyl)amino]acetic acid;2-oxopentanedioic acid
• CAS: 315669-78-4
• 化学式: C9H15N3O7
• 分子量: 277.23
• InChiKey: VSQHMIFYITYXRG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  182
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• Compositions and methods for neuroprotection and treatment of neurodegeneration
  申请人：Vireo Systems, Inc.

  公开号：US10245245B2

  公开（公告）日：2019-04-02

  Compositions for neuroprotection and treatment of neurodegeneration and methods of administering same. In particular, the present invention relates to compositions and methods for preventing or reducing neurodegeneration, such as neurodegeneration caused by Huntington's disease, including administering a daily dose of a composition including an effective amount of creatine hydrochloride to a patient in need thereof. The methods of the present invention allow for lower dosages of supplementation as compared to creatine monohydrate while retaining all of the desired biological effects of creatine supplementation.

  用于神经保护和治疗神经变性的组合物及其施用方法。特别是，本发明涉及预防或减少神经变性（如亨廷顿氏病引起的神经变性）的组合物和方法，包括向有需要的患者施用每日剂量的组合物（包括有效量的盐酸肌酸）。与一水肌酸相比，本发明的方法可以降低补充剂量，同时保留肌酸补充的所有预期生物效应。
• Creatine oral supplementation using creatine hydrochloride salt
  申请人：Vireo Systems, Inc.

  公开号：US10342771B2

  公开（公告）日：2019-07-09

  The present invention is directed to an oral supplement including creatine hydrochloride, which has an aqueous solubility that is at least 15 times greater than creatine monohydrate, where the oral supplement drives significant improvements in muscle development and recovery due to its enhanced bio-availability, while causing fewer negative side effects compared to previous forms of creatine.

  本发明涉及一种口服补充剂，其中包括盐酸肌酸，其水溶性至少是一水肌酸的 15 倍，与以往形式的肌酸相比，这种口服补充剂因其生物利用率的提高而显著改善了肌肉的发育和恢复，同时产生的负面副作用也更少。
• Compositions for reducing mitochondrial dysfunction
  申请人：Dischler Louis

  公开号：US11090320B2

  公开（公告）日：2021-08-17

  Disclosed are methods and compositions for reducing the epigenetic age of organisms, especially that of adult humans, which provide for proliferating endogenous stem cells, removing aberrant epigenetic marks from chromosomes and mitochondrial DNA, and replacement of senescent cells.

  所公开的是降低生物体（尤其是成年人类）表观遗传年龄的方法和组合物，可用于增殖内源性干细胞、去除染色体和线粒体 DNA 上的异常表观遗传标记以及替换衰老细胞。
• Compositions and methods for treatment of inflammation
  申请人：Vireo Systems, Inc.

  公开号：US11058655B2

  公开（公告）日：2021-07-13

  The present invention is directed to novel anti-inflammatory immunomodulators including creatinine or a creatinine salt, for example, creatinine hydrochloride. The present invention is also directed to methods for treating inflammation and inducing an immunomodulatory response. In particular, the anti-inflammatory immunomodulators are useful for treating an inflammatory condition or an autoimmune disease.

  本发明涉及新型抗炎免疫调节剂，包括肌酐或肌酐盐，例如盐酸肌酐。本发明还涉及治疗炎症和诱导免疫调节反应的方法。特别是，抗炎免疫调节剂可用于治疗炎症或自身免疫性疾病。
• Methods for reducing mitochondrial dysfunction
  申请人：Dischler Louis

  公开号：US11324764B2

  公开（公告）日：2022-05-10

  Disclosed are methods and compositions for reducing the epigenetic age of organisms, especially that of adult humans, which provide for proliferating endogenous stem cells, removing aberrant epigenetic marks from chromosomes and mitochondrial DNA, and replacement of senescent cells.

  所公开的是降低生物体（尤其是成年人类）表观遗传年龄的方法和组合物，可用于增殖内源性干细胞、去除染色体和线粒体 DNA 上的异常表观遗传标记以及替换衰老细胞。