2-[[2-[Bis(carboxymethyl)amino]-3-[(4,4-diphenylcyclohexyl)oxy-hydroxyphosphoryl]oxypropyl]-[2-[bis(carboxymethyl)amino]ethyl]amino]acetic acid | 1070874-18-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[[2-[Bis(carboxymethyl)amino]-3-[(4,4-diphenylcyclohexyl)oxy-hydroxyphosphoryl]oxypropyl]-[2-[bis(carboxymethyl)amino]ethyl]amino]acetic acid
• CAS: 1070874-18-8
• 化学式: C₃₃H₄₄N₃O₁₄P
• 分子量: 737.7
• InChiKey: NZLPWFTXPYJYSS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5
• 重原子数：
  51
• 可旋转键数：
  23
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  252
• 氢给体数：
  6
• 氢受体数：
  17

文献信息

• Diagnostic imaging contrast agents with extended blood retention
  申请人：McMurry J. Thomas

  公开号：US20070003479A1

  公开（公告）日：2007-01-04

  The present invention relates to contrast agents for diagnostic imaging with prolonged blood retention. In particular, this invention relates to novel compounds that are characterized by an image enhancing moiety (IEM); a protein plasma binding moiety (PPBM); and a blood half-life extending moiety (BHEM). This invention also relates to pharmaceutical compositions comprising these compounds and to methods of using the compounds and compositions for blood half-life extension and contrast enhancement of diagnostic imaging.

  本发明涉及用于诊断成像的对比剂，其具有延长血液滞留时间的特性。特别地，本发明涉及一种新型化合物，其特征为具有增强成像部分（IEM）；蛋白质血浆结合部分（PPBM）；和延长血液半衰期部分（BHEM）。本发明还涉及包括这些化合物的制药组合物以及使用这些化合物和组合物进行血液半衰期延长和诊断成像对比增强的方法。
• Multi-mode medical device system with thermal ablation capability and methods of using same
  申请人：Unal Orhan

  公开号：US20080183070A1

  公开（公告）日：2008-07-31

  A multi-mode medical device system and method of using same to perform an interventional procedure. The multi-mode medical device system includes a medical device and an electrical circuit coupled to the medical device. The electrical circuit includes an integrated tracking device (e.g., a solenoid) and an imaging/visualizing device (e.g., a resonant loop). The multi-mode medical device system also includes a thermal ablation device coupled to the medical device and to the tracking device.

  一种多模式医疗设备系统及其使用方法，用于执行介入性手术。多模式医疗设备系统包括医疗设备和与医疗设备耦合的电路。电路包括集成跟踪装置（例如，电磁线圈）和成像/可视化装置（例如，共振环）。多模式医疗设备系统还包括与医疗设备和跟踪装置耦合的热消融装置。
• Voltage standing wave suppression for MR-guided therapeutic interventions
  申请人：Kurpad Krishna N.

  公开号：US20080208031A1

  公开（公告）日：2008-08-28

  A system and method of tracking a medical device and generating an image of a target area. The medical device includes a tracking device to create an imaging field-of-view that extends beyond the tip of the medical device while allowing the tip of the medical device to be visualized. The medical device further includes an imaging/visualization device to create an imaging field from the point of view of the medical device. A voltage standing wave suppression device is formed on the exterior surface of the medical device to prevent the formation of voltage standing waves and localized tissue heating. The voltage standing wave suppression device includes two cable traps spaced apart from one another with each cable trap being formed of a closely packed coiled region of a conductor extending the length of the medical device.

  一种追踪医疗设备并生成目标区域图像的系统和方法。医疗设备包括一个追踪设备，以创建超出医疗设备尖端的成像视野，同时允许医疗设备尖端可视化。医疗设备还包括一个成像/可视化设备，以从医疗设备的视角创建成像视野。在医疗设备的外部表面上形成一个电压驻波抑制装置，以防止电压驻波和局部组织加热的形成。电压驻波抑制装置包括两个电缆陷阱，相互间隔，每个电缆陷阱由医疗设备长度的一个紧密包绕的导体区域形成。
• Medical device system and method for tracking and visualizing a medical device system under MR guidance
  申请人：Unal Orhan

  公开号：US20070156042A1

  公开（公告）日：2007-07-05

  A medical device system capable of being tracked and visualized using a magnetic resonance (MR) device, and a method for tracking and visualizing a medical device system using MR imaging. The medical device system can include a medical device, a tracking device, and a visualizing device. The tracking device can provide feedback indicative of the position of the tracking device. The visualizing device can be coupled to at least a portion of the medical device such that the respective portion of the medical device is visualized using magnetic resonance. The method for tracking and visualizing a medical device system can include providing a medical device having a nonlinear configuration, tracking a tracking device, and visualizing a visualizing device to allow visualization of the nonlinear configuration of the medical device. Some embodiments include a medical device system capable of being visualized in the presence and absence of contrast agents.

  一种医疗设备系统，可以使用磁共振（MR）设备进行跟踪和可视化，并且一种使用MR成像跟踪和可视化医疗设备系统的方法。医疗设备系统可以包括医疗设备、跟踪设备和可视化设备。跟踪设备可以提供反馈，指示跟踪设备的位置。可视化设备可以与医疗设备的至少一部分耦合，以便使用磁共振可视化各自部分的医疗设备。跟踪和可视化医疗设备系统的方法可以包括提供具有非线性配置的医疗设备，跟踪跟踪设备，并可视化可视化设备，以允许可视化医疗设备的非线性配置。一些实施例包括一种医疗设备系统，能够在有和没有对比剂的情况下被可视化。
• System and method for simultaneous 3DPR device tracking and imaging under MR-guidance for therapeutic endovascular interventions
  申请人：Unal Orhan

  公开号：US20080114235A1

  公开（公告）日：2008-05-15

  A system and method of both tracking a medical device and generating an image in real time from the same set of radial data. A multi-mode medical device system having tracking, imaging, and visualizing capabilities is coupled to an MR scanner and multiple-echo VIPR acquisition sequence is applied to simultaneously provide conventional real-time imaging of the target region using an external coil, 3D tip-tracking information, and a localized higher-quality image showing the region surrounding the medical device using an internal multi-mode coil.

  一种系统和方法，既可以跟踪医疗设备，又可以从同一组径向数据中实时生成图像。一个具有跟踪、成像和可视化能力的多模医疗设备系统与MR扫描仪相连，并应用多回波VIPR采集序列，同时使用外部线圈提供目标区域的常规实时成像、3D尖端跟踪信息和使用内部多模线圈显示医疗设备周围区域的局部高质量图像。