4-[(4-chlorophenyl)methyl]-3-oxo-N-[(1S)-1-[4-(5-oxo-4H-1,2,4-oxadiazol-3-yl)phenyl]ethyl]-1,4-benzoxazine-5-carboxamide | 1097195-00-0

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 4-[(4-chlorophenyl)methyl]-3-oxo-N-[(1S)-1-[4-(5-oxo-4H-1,2,4-oxadiazol-3-yl)phenyl]ethyl]-1,4-benzoxazine-5-carboxamide
• CAS: 1097195-00-0
• 化学式: C₂₆H₂₁ClN₄O₅
• 分子量: 504.93
• InChiKey: VTOKZPOYTGYWKH-HNNXBMFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  36
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• AMIDE COMPOUNDS
  申请人：Nozawa Eisuke

  公开号：US20110028463A1

  公开（公告）日：2011-02-03

  [Problems] To provide a compound that is useful as an agent for treating chronic renal insufficiency or an agent for treating diabetic nephropathy. [Means for Solving Problems] The present inventors have conducted extensive studies on a compound having an EP4 receptor antagonistic action, and as a result, they have found that various amide derivatives having a carboxylic group or an equivalent thereof exhibit an excellent EP4 receptor antagonistic action, thereby completing the present invention. Since the compound of the present invention has an excellent EP4 receptor antagonistic action, it is useful as an agent for preventing and/or treating chronic renal insufficiency or diabetic nephropathy.

  【问题】提供一种可用作治疗慢性肾功能不全或糖尿病肾病的药物化合物。 【解决问题的方法】本发明者对具有EP4受体拮抗作用的化合物进行了广泛的研究，结果发现具有羧酸基或其等效物的各种酰胺衍生物表现出优异的EP4受体拮抗作用，从而完成了本发明。由于本发明的化合物具有优异的EP4受体拮抗作用，因此可用作预防和/或治疗慢性肾功能不全或糖尿病肾病的药物。