2-Amino-4-(4-hydroxyanilino)-5-(4-methoxyphenylethynyl)pyrimidine | 393856-24-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-Amino-4-(4-hydroxyanilino)-5-(4-methoxyphenylethynyl)pyrimidine
• 英文别名: Phenol, 4-[[2-amino-5-[(4-methoxyphenyl)ethynyl]-4-pyrimidinyl]amino]-；4-[[2-amino-5-[2-(4-methoxyphenyl)ethynyl]pyrimidin-4-yl]amino]phenol
• CAS: 393856-24-1
• 化学式: C₁₉H₁₆N₄O₂
• 分子量: 332.362
• InChiKey: GKTNELAXDKPPQC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  93.3
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Substituted 5-alkynyl pyrimidines having neurotrophic activity
  申请人：——

  公开号：US20040087789A1

  公开（公告）日：2004-05-06

  The present invention relates to a series of novel substituted 5-alkynyl pyrimidines, pharmaceutical compositions which contain them, methods for their preparation, and their use in therapy, particularly in the treatment of neurodegenerative or other neurological disorders of the central and peripheral nervous systems, including age related cognitive disorders such as senility and Alzheimer's disease, nerve injuries, peripheral neuropathies, and seizure disorders such as epilepsy.

  本发明涉及一系列新颖的取代的5-炔基嘧啶类化合物，包含它们的药物组合物，它们的制备方法，以及它们在治疗中的应用，特别是在中枢和外周神经系统的神经退行性或其他神经系统疾病的治疗中，包括与年龄相关的认知障碍如老年痴呆症和阿尔茨海默病、神经损伤、外周神经病和癫痫等癫痫病的治疗。
• [EN] SUBSTITUTED 5-ALKYNYL PYRIMIDINES HAVING NEUROTROPHIC ACTIVITY<br/>[FR] 5-ALKYNYLE PYRIMIDINES SUBSTITUEES AVEC ACTIVITE NEUROTROPHIQUE
  申请人：KRENITSKY PHARMACEUTICALS INC

  公开号：WO2002008205A1

  公开（公告）日：2002-01-31

  The present invention relates to a series of novel substituted 5-alkynyl pyrimidines, pharmaceutical compositions which contain them, methods for their preparation, and their use in therapy, particularly in the treatment of neurodegenerative or other neurological disorders of the central and peripheral nervous systems, including age related cognitive disorders such as senility and Alzheimer's disease, nerve injuries, peripheral neuropathies, and seizure disorders such as epilepsy.

  本发明涉及一系列新的取代的5-炔基嘧啶，包含它们的制药组合物，制备方法以及它们在治疗中的使用，特别是在中枢和外周神经系统的神经退行性或其他神经系统障碍的治疗中，包括与年龄相关的认知障碍，如老年痴呆症，神经损伤，外周神经病变和癫痫等癫痫症状的治疗。
• SUBSTITUTED 5-ALKYNYL PYRIMIDINES HAVING NEUROTROPHIC ACTIVITY
  申请人：Krenitsky Pharmaceuticals, Inc.

  公开号：EP1303495A1

  公开（公告）日：2003-04-23
• US7205297B2
  申请人：——

  公开号：US7205297B2

  公开（公告）日：2007-04-17