非诺贝特杂质15 | 34183-01-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 非诺贝特杂质15
• 英文名称: 4-hydroxy-2',4'-dichlorobenzophenone
• 英文别名: (2,4-Dichlorophenyl)(4-hydroxyphenyl)methanone；(2,4-dichlorophenyl)-(4-hydroxyphenyl)methanone
• CAS: 34183-01-2
• 化学式: C₁₃H₈Cl₂O₂
• 分子量: 267.111
• InChiKey: JAMXQHSUUYEFGH-UHFFFAOYSA-N

物化性质

• 熔点：
  140 °C
• 沸点：
  435.4±40.0 °C(Predicted)
• 密度：
  1.406±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  非诺贝特杂质15 在 溶剂黄146 、 肼 作用下， 以 吡啶 、 乙醇 为溶剂， 生成 trifluoro-methanesulfonic acid 4-[(2,4-dichloro-phenyl)-hydrazono-methyl]-phenyl ester
  参考文献：
  名称：

  具有杀虫活性的二苯甲酮derivatives衍生物的合成及其构效关系。

  摘要：

  制备了广泛的二苯甲酮衍生物，并针对选定的咀嚼害虫进行了测试，从而分析了结构-活性关系。仅当芳环在4-位被卤素原子和三氟甲磺酸酯或全卤代烷氧基取代时，才发现良好的活性。相反，部分上的许多取代基导致活性化合物，用酰基型取代基可获得最佳结果。在针对斜纹夜蛾的半田间试验中证实了最佳代表的出色的实验室和温室活性。

  DOI：

  10.1002/1526-4998(200102)57:2<191::aid-ps275>3.0.co;2-o
• 作为产物：
  描述：

  (2,4-二氯苯基)(4-甲氧基苯基)甲酮 生成 非诺贝特杂质15
  参考文献：
  名称：

  具有杀虫活性的二苯甲酮derivatives衍生物的合成及其构效关系。

  摘要：

  制备了广泛的二苯甲酮衍生物，并针对选定的咀嚼害虫进行了测试，从而分析了结构-活性关系。仅当芳环在4-位被卤素原子和三氟甲磺酸酯或全卤代烷氧基取代时，才发现良好的活性。相反，部分上的许多取代基导致活性化合物，用酰基型取代基可获得最佳结果。在针对斜纹夜蛾的半田间试验中证实了最佳代表的出色的实验室和温室活性。

  DOI：

  10.1002/1526-4998(200102)57:2<191::aid-ps275>3.0.co;2-o

文献信息

• Substituted aminoalkoxybenzene anti-fungicidal compositions and use
  申请人：Hoffmann-La Roche Inc.

  公开号：US05214046A1

  公开（公告）日：1993-05-25

  The compound of the formula ##STR1## wherein each of R.sup.1 and R.sup.2 individually is hydrogen, lower alkyl or lower alkenyl or together signify straight-chain alkylene with 2 to 4 carbon atoms, R.sup.3 is hydrogen, halogen or lower alkyl, Q is alkylene with 4 to 11 carbon atoms and at least 4 carbon atoms between the two free valencies or alkenylene with 4 to 11 carbon atoms and at least 4 carbon atoms between the two free valencies and each of Y and Y' individually is a direct bond or the group --CH.sub.2 --, --CH.sub.2 CH.sub.2 --, --CH.dbd.CH-- or --C.tbd.C--, the group R.sup.1 R.sup.2 N--Q--O-- is attached to the 3- or 4 -position of ring A and the symbol R designates that the ring to which it is attached is unsubstituted or is substituted with at least one substitutent selected from the group consisting of halogen, trifluoromethyl, cyano, nitro, lower alkyl and lower alkoxy, and their pharmaceutically acceptable acid addition salts can be used for the control or prevention of fungal infections, especially of topical or systemic infections which are caused by pathogenic fungi, and for the manufacture of antifungally-active medicaments. The compounds of formula I have not only a pronounced antifungal activity, but they also exhibit synergistic effects in combination with other known antifungally-active substances which inhibit sterol biosynthesis such as ketoconazole and terbinafine.

  该化合物的化学式为##STR1##，其中R.sup.1和R.sup.2分别为氢、低碳烷基或低碳烯基，或者一起表示具有2至4个碳原子的直链烷基；R.sup.3为氢、卤素或低碳烷基；Q为具有4至11个碳原子且两个自由价键之间至少有4个碳原子的烷基，或者具有4至11个碳原子且两个自由价键之间至少有4个碳原子的烯基；Y和Y'中的每一个都是直接键或基团--CH.sub.2 --、--CH.sub.2 CH.sub.2 --、--CH.dbd.CH--或--C.tbd.C--；基团R.sup.1 R.sup.2 N--Q--O--连接到环A的3-或4-位置，符号R表示其连接的环未被取代或者被取代至少一个取代基，该取代基可从卤素、三氟甲基、氰基、硝基、低碳烷基和低碳烷氧基组成的群体中选择，且它们的药学上可接受的酸盐可用于控制或预防由致病真菌引起的真菌感染，特别是局部或全身感染，用于制造具有抗真菌活性的药物。化合物I的化学式不仅具有明显的抗真菌活性，而且与其他已知抑制固醇生物合成的抗真菌活性物质（如酮康唑和特比萘芬）结合时还表现出协同效应。
• NITROGENATED AROMATIC COMPOUND, PROCESS FOR PRODUCTION OF THE SAME, POLYMER, AND PROTON CONDUCTIVE MEMBRANE
  申请人：Higami Makoto

  公开号：US20090149623A1

  公开（公告）日：2009-06-11

  A nitrogen-containing aromatic compound is represented by Formula (1). A polymer is obtained by polymerizing the compound. wherein X is an atom or a group selected from halogen atoms other than fluorine and —OSO 2 Rb (wherein Rb is an alkyl group, a fluorine-substituted alkyl group or an aryl group); Y is at least one structure selected from the group consisting of —CO—, —SO 2 —, —SO—, —CONH—, —COO—, —(CF 2 ) l — (wherein l is an integer of 1 to 10) and —C(CF 3 ) 2 —; Z is at least one structure selected from the group consisting of a direct bond, —O— and —S—; R 20 is a nitrogen-containing heterocyclic group; q is an integer of 1 to 5; and p is an integer of 0 to 4.

  一个含氮芳香化合物由式（1）表示。通过聚合该化合物得到一种聚合物。其中X是从卤素原子（不包括氟）和—OSO2Rb（其中Rb是烷基、氟取代烷基或芳基）中选择的一个原子或基团；Y是从—CO—、—SO2—、—SO—、—CONH—、—COO—、—（CF2）l—（其中l为1至10的整数）和—C(CF3)2—中选择的至少一个结构；Z是从直接键、—O—和—S—中选择的至少一个结构；R20是含氮杂环基团；q是1至5的整数；p是0至4的整数。
• ELECTRODE ELECTROLYTE FOR USE IN SOLID POLYMER FUEL CELL
  申请人：Higami Makoto

  公开号：US20090130526A1

  公开（公告）日：2009-05-21

  This invention provides an electrode electrolyte for a solid polymer-type fuel cell, in which a cost problem and a problem related to recovery of catalyst metals are solved, having excellent proton conductivity, dimensional stability and heat resistance. An electrode electrolyte for a solid polymer electrolyte-type fuel cell contains a polymer, which has a polyphenylene structure as a main chain and both a sulfonic acid group and a nitrogen-containing heterocyclic group as a side chain. A side chain having the nitrogen-containing heterocyclic group has a structure represented by the following general formula (D). (In formula, Z represents at least one kind of structures selected from a group consisting of a direct bond, —O— and —S—, Y represents at least one kind of structures selected from a group consisting of —CO—, —SO 2 —, —SO—, —CONH—, —COO—, —(CF 2 ) 1 — (1 is an integer of 1 to 10) and —C(CF 3 ) 2 — and R 20 represents a nitrogen-containing heterocyclic group. q represents an integer of 1 to 5 and p represents an integer of 0 to 4.) The above nitrogen-containing heterocyclic group is at least one kind of group derived from a compound selected from the group consisting of nitrogen-containing heterocyclic compounds including pyrrole, thiazole, isothiazole, oxazole, isoxazole, pyridine, imidazole, imidazoline, pyrazole, 1,3,5-triazine, pyrimidine, pyridazine, pyrazine, indole, quinoline, isoquinoline, purine, benzimidazole, benzoxazole, benzothiazole, tetrazole, tetrazine, triazole, carbazole, acridine, quinoxaline and quinazoline and derivatives thereof.

  该发明提供了一种用于固体聚合物型燃料电池的电极电解质，解决了成本问题和催化金属回收问题，具有优异的质子导电性、尺寸稳定性和耐热性。该固体聚合物电解质型燃料电池的电极电解质包含一种聚合物，其主链具有聚苯基结构，侧链具有磺酸基和含氮杂环基团。具有含氮杂环基团的侧链具有以下通式（D）所表示的结构。（式中，Z代表从直接键，—O—和—S—中选择的至少一种结构；Y代表从—CO—，—SO2—，—SO—，—CONH—，—COO—，—（CF2）1—（1是1到10的整数）和—C（CF3）2—中选择的至少一种结构；R20代表一个含氮杂环基团；q代表1到5的整数，p代表0到4的整数。）上述含氮杂环基团是从包括吡咯、噻唑、异噻唑、噁唑、异噁唑、吡啶、咪唑、咪唑啉、吡唑啉、1,3,5-三嗪、嘧啶、吡嗪、吡嗪嗪、吡咯烷、喹啉、异喹啉、嘧啶、苯并咪唑、苯并噁唑、苯并噻唑、四唑、四唑嗪、三唑、咔唑、蒽啉、喹喔啉和喹唑啉及其衍生物中选择的化合物衍生的至少一种基团。
• Membrane-electrode assembly for solid polymer electrolyte fuel cell
  申请人：Kanaoka Nagayuki

  公开号：US20070015024A1

  公开（公告）日：2007-01-18

  A membrane-electrode assembly for solid polymer electrolyte fuel cells, in which a sulfonic acid is an ion exchange group, and the heat resistance is superior, is provided. The membrane-electrode assembly for solid polymer electrolyte fuel cells contains a polymer including a principal chain that forms polyphenylene structure, a branched chain having a sulfonic acid group, and a branched chain having a nitrogen-containing heterocyclic group. It is preferred that a branched chain having a nitrogen-containing heterocyclic group is a structure expressed by the general formula (D) below.

  提供了一种用于固体聚合物电解质燃料电池的膜电极组件，其中磺酸是离子交换基团，具有优异的耐热性。该固体聚合物电解质燃料电池的膜电极组件包含一种聚苯乙烯结构的主链聚合物，具有一个带有磺酸基团的支链和一个带有含氮杂环基团的支链。最好的情况是，带有含氮杂环基团的支链是以下通式（D）表示的结构。
• MEMBRANE-ELECTRODE ASSEMBLY FOR SOLID POLYMER ELECTROLYTE FUEL CELL
  申请人：NAKAGAWA Takaki

  公开号：US20100062311A1

  公开（公告）日：2010-03-11

  A membrane-electrode assembly for a solid polymer electrolyte fuel cell is provided that uses a proton conductive membrane having high proton conductivity and also superior heat resistance and chemical durability. A membrane-electrode assembly for a solid polymer electrolyte fuel cell is provided with an anode on one side of a proton conductive membrane and a cathode on another side thereof, and the proton conductive membrane is a sulfonated polyarylene containing a structure expressed by the general formula (1) below: —R s —Z—R h (1) In the formula (1), Z represents at least one structure selected from the group consisting of —CO—, —SO 2 —, and —SO—; R s represents a direct bond or any divalent organic group; and R h represents a nitrogen-containing heterocyclic group.

  提供一种用于固体聚合物电解质燃料电池的膜电极组件，该组件使用具有高质子传导性、优异耐热性和化学耐久性的质子传导膜。该固体聚合物电解质燃料电池的膜电极组件，在质子传导膜的一侧具有阳极，在另一侧具有阴极，而质子传导膜是一种含有以下通式（1）所表示结构的磺化聚芳烃：—Rs—Z—Rh（1）其中，在式（1）中，Z表示选自—CO—、—SO2—和—SO—的至少一种结构；Rs表示直接键或任何二价有机基团；而Rh表示含氮杂环基团。