1,1-二氟螺[2.3]己烷-5-胺盐酸盐 | 1955540-34-7

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氟化物
• 中文名称: 1,1-二氟螺[2.3]己烷-5-胺盐酸盐
• 英文名称: 1,1-difluorospiro[2.3]hexan-5-amine hydrochloride
• 英文别名: 2,2-difluorospiro[2.3]hexan-5-amine;hydrochloride
• CAS: 1955540-34-7
• 化学式: C₆H₉F₂N*ClH
• 分子量: 169.602
• InChiKey: WGDAQAXOMRICLG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.55
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,1-二氟螺[2.3]己烷-5-胺盐酸盐 、 4-nitrophenyl (3-(trifluoromethyl)benzyl)carbamate 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 生成 1-(1,1-difluorospiro[2.3]hex-5-yl)-3-(3-trifluoromethylbenzyl)urea
  参考文献：
  名称：

  [EN] SPIROUREA DERIVATIVES
  [FR] DÉRIVÉS SPIROS D'URÉE

  摘要：

  该发明涉及式（I）化合物，其中X1、X2、X3、Y、R1、R2A、R2B、R3和R4如描述中所述；其制备方法，其药学上可接受的盐，含有一种或多种式（I）化合物的药物组合物，以及将这些化合物用作药物，特别是作为Kv7开放剂的用途。

  公开号：

  WO2021219594A1
• 作为产物：
  描述：

  1,1-二氟螺[2.3]己烷-5-羧酸 在 叠氮磷酸二苯酯 、 三乙胺 、 盐酸 作用下， 以 叔丁醇 、 1,4-二氧六环 、 水 为溶剂， 以84%的产率得到1,1-二氟螺[2.3]己烷-5-胺盐酸盐
  参考文献：
  名称：

  官能化的二氟环丙烷的合成：药物发现的独特组成部分

  摘要：

  由功能化烯烃和TMSCF 3 / NaI合成了用于药物发现的含二氟环丙烷的结构单元。获得了新颖的氟化酸，胺，氨基酸，醇，酮和磺酰氯。

  DOI：

  10.1002/chem.201705708

文献信息

• Cyano cyclobutyl compounds for CBL-B inhibition and uses thereof
  申请人：Nurix Therapeutics, Inc.

  公开号：US11530229B2

  公开（公告）日：2022-12-20

  Compounds, compositions, and methods for use in inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway are disclosed. The compounds, compositions, and methods can be used to modulate the immune system, to treat diseases amenable to immune system modulation, and for treatment of cells in vivo, in vitro, or ex vivo. Also disclosed are pharmaceutical compositions comprising a Cbl-b inhibitor and a cancer vaccine, as well as methods for treating cancer using a Cbl-b inhibitor and a cancer vaccine; and pharmaceutical compositions comprising a Cbl-b inhibitor and an oncolytic virus, as well as methods for treating cancer using a Cbl-b inhibitor and an oncolytic virus.

  本发明公开了用于抑制泛素蛋白酶体途径中的 E3 酶 Cbl-b 的化合物、组合物和方法。这些化合物、组合物和方法可用于调节免疫系统，治疗免疫系统可调节的疾病，以及体内、体外或体外细胞的治疗。还公开了包含 Cbl-b 抑制剂和癌症疫苗的药物组合物，以及使用 Cbl-b 抑制剂和癌症疫苗治疗癌症的方法；以及包含 Cbl-b 抑制剂和溶瘤病毒的药物组合物，以及使用 Cbl-b 抑制剂和溶瘤病毒治疗癌症的方法。
• CYANO CYCLOBUTYL COMPOUNDS FOR CBL-B INHIBITION AND USES THEREOF
  申请人：Nurix Therapeutics, Inc.

  公开号：US20210053986A1

  公开（公告）日：2021-02-25

  Compounds, compositions, and methods for use in inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway are disclosed. The compounds, compositions, and methods can be used to modulate the immune system, to treat diseases amenable to immune system modulation, and for treatment of cells in vivo, in vitro, or ex vivo. Also disclosed are pharmaceutical compositions comprising a Cbl-b inhibitor and a cancer vaccine, as well as methods for treating cancer using a Cbl-b inhibitor and a cancer vaccine; and pharmaceutical compositions comprising a Cbl-b inhibitor and an oncolytic virus, as well as methods for treating cancer using a Cbl-b inhibitor and an oncolytic virus.
• [EN] CYANO CYCLOBUTYL COMPOUNDS FOR CBL-B INHIBITION AND USES THEREOF<br/>[FR] COMPOSÉS CYANO-CYCLOBUTYLE POUR L'INHIBITION DE CBL-B ET LEURS UTILISATIONS
  申请人：NURIX THERAPEUTICS INC

  公开号：WO2020236654A1

  公开（公告）日：2020-11-26

  Compounds, compositions, and methods for use in inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway are disclosed. The compounds, compositions, and methods can be used to modulate the immune system, to treat diseases amenable to immune system modulation, and for treatment of cells in vivo, in vitro, or ex vivo. Also disclosed are pharmaceutical compositions comprising a Cbl-b inhibitor and a cancer vaccine, as well as methods for treating cancer using a Cbl-b inhibitor and a cancer vaccine; and pharmaceutical compositions comprising a Cbl-b inhibitor and an oncolytic virus, as well as methods for treating cancer using a Cbl-b inhibitor and an oncolytic virus.
• WO2023/91461
  申请人：——

  公开号：——

  公开（公告）日：——