3,5-Bis-(4-acetylamino-phenoxy)-benzoyl chloride | 1005197-21-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,5-Bis-(4-acetylamino-phenoxy)-benzoyl chloride
• CAS: 1005197-21-6
• 化学式: C₂₃H₁₉ClN₂O₅
• 分子量: 438.867
• InChiKey: VKUKNZGEGLKQCL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.57
• 重原子数：
  31.0
• 可旋转键数：
  7.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  93.73
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  3,5-二(4-氨基苯氧基)苯甲酸 、 3,5-Bis-(4-acetylamino-phenoxy)-benzoyl chloride 以 N-甲基吡咯烷酮 为溶剂， 反应 4.0h， 生成 3,5-Bis[4-[[3,5-bis[4-(1-hydroxyethylideneamino)phenoxy]benzoyl]amino]phenoxy]benzoic acid
  参考文献：
  名称：

  Facile Synthesis of Polyamide Dendrimers from Unprotected AB₂ Building Blocks

  摘要：

  A fast, inexpensive, and highly efficient synthesis of aromatic polyamide dendrimers; without the need for protection and deprotection steps has been developed. Dendrons and third-generation polyamide dendrimers were easily prepared by a convergent approach involving activation of a focal point with thionyl chloride, followed by condensation with unprotected AB(2) building blocks.

  DOI：

  10.1021/ol035595s
• 作为产物：
  描述：

  3,5-双(4-乙酰氨基苯氧基)苯甲酸 在 氯化亚砜 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 0.5h， 生成 3,5-Bis-(4-acetylamino-phenoxy)-benzoyl chloride
  参考文献：
  名称：

  Facile Synthesis of Polyamide Dendrimers from Unprotected AB₂ Building Blocks

  摘要：

  A fast, inexpensive, and highly efficient synthesis of aromatic polyamide dendrimers; without the need for protection and deprotection steps has been developed. Dendrons and third-generation polyamide dendrimers were easily prepared by a convergent approach involving activation of a focal point with thionyl chloride, followed by condensation with unprotected AB(2) building blocks.

  DOI：

  10.1021/ol035595s