ethyl 2-[[(3S)-3-[[(2S)-3-cyclohexyl-2-[(2-oxo-2-thiophen-2-ylacetyl)amino]propanoyl]amino]-2-oxo-4-phenylmethoxybutanoyl]amino]acetate | 1229294-45-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethyl 2-[[(3S)-3-[[(2S)-3-cyclohexyl-2-[(2-oxo-2-thiophen-2-ylacetyl)amino]propanoyl]amino]-2-oxo-4-phenylmethoxybutanoyl]amino]acetate
• CAS: 1229294-45-4
• 化学式: C₃₀H₃₇N₃O₈S
• 分子量: 599.705
• InChiKey: LNFIRMPLOWNYDD-GOTSBHOMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  42
• 可旋转键数：
  17
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  185
• 氢给体数：
  3
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  ethyl 2-[[(3S)-3-[[(2S)-3-cyclohexyl-2-[(2-oxo-2-thiophen-2-ylacetyl)amino]propanoyl]amino]-2-hydroxy-4-phenylmethoxybutanoyl]amino]acetate 在 戴斯-马丁氧化剂 作用下， 以 二氯甲烷 为溶剂， 生成 ethyl 2-[[(3S)-3-[[(2S)-3-cyclohexyl-2-[(2-oxo-2-thiophen-2-ylacetyl)amino]propanoyl]amino]-2-oxo-4-phenylmethoxybutanoyl]amino]acetate
  参考文献：
  名称：

  Design and Synthesis of α-Ketoamides as Cathepsin S Inhibitors with Potential Applications against Tumor Invasion and Angiogenesis

  摘要：

  A series of small molecules bearing an alpha-ketoamide warhead were synthesized and evaluated for their ability to inhibit cathepsin S, a key proteolytic enzyme upregulated in many cancers during tumor progression and metastasis. Most of the synthetic compounds were noncytotoxic, but several robustly inhibited cathepsin S (IC(50) < 10 nM) and potently suppressed cell migration, invasion, and capillary tube formation. These results highlight the potential of alpha-ketoamide therapy for preventing or delaying cancer spread.

  DOI：

  10.1021/jm100089e