3-(3-((tert-butyldiphenylsilyl)oxy)propyl)-2-chloro-6-methylpyrimidin-4(3H)-one | 1191918-46-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 3-(3-((tert-butyldiphenylsilyl)oxy)propyl)-2-chloro-6-methylpyrimidin-4(3H)-one
• CAS: 1191918-46-3
• 化学式: C₂₄H₂₉ClN₂O₂Si
• 分子量: 441.045
• InChiKey: HXISJNUDUCUNDQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.17
• 重原子数：
  30.0
• 可旋转键数：
  7.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  44.12
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  3-(3-((tert-butyldiphenylsilyl)oxy)propyl)-2-chloro-6-methylpyrimidin-4(3H)-one 、 N-Boc-哌嗪 在 potassium carbonate 作用下， 以 EtCN 为溶剂， 生成 tert-butyl 4-(1-(3-((tert-butyldiphenylsilyl)oxy)propyl)-4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)piperazine-1-carboxylate
  参考文献：
  名称：

  Design and synthesis of piperazinylpyrimidinones as novel selective 5-HT2C agonists

  摘要：

  This Letter reports the design and synthesis of several novel series of piperazinyl pyrimidinones as 5-HT2C agonists. Several of the compounds presented exhibit good in vitro potency and selectivity over the closely related 5-HT2A and 5-HT2B receptors. Compound 11 was active in in vivo models of stress urinary incontinence. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.07.133
• 作为产物：
  描述：

  C₂₄H₃₀N₂O₂SSi 在 草酰氯 、 N,N-二甲基甲酰胺 作用下， 以 二氯甲烷 为溶剂， 以80%的产率得到3-(3-((tert-butyldiphenylsilyl)oxy)propyl)-2-chloro-6-methylpyrimidin-4(3H)-one
  参考文献：
  名称：

  Design and synthesis of piperazinylpyrimidinones as novel selective 5-HT2C agonists

  摘要：

  This Letter reports the design and synthesis of several novel series of piperazinyl pyrimidinones as 5-HT2C agonists. Several of the compounds presented exhibit good in vitro potency and selectivity over the closely related 5-HT2A and 5-HT2B receptors. Compound 11 was active in in vivo models of stress urinary incontinence. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.07.133