It is shown that TPL-2 is responsible for phosphorylation of p105 and its resultant proteolysis, which leads to p50 Rel translocation to the nucleus. Accordingly, the invention provides TPL-2 as a specific regulator of the activation of NF&kgr;B, and thus as a modulator of inflammatory responses in which p105 is involved, and as a target for the development of compounds capable of influencing NF&kgr;B activation.
研究表明,TP
L-2 负责 p105 的
磷酸化和由此产生的蛋白
水解,从而导致 p50 Rel 转位至细胞核。因此,本发明提供的 TP
L-2 是 NF&kgr;B 活化的特异性调节剂,因而是 p105 参与的炎症反应的调节剂,也是开发能够影响 NF&kgr;B 活化的化合物的靶标。