3-(biphenyl-3-yl)-2-(4-ethylphenyl)-1-methyl-1H-indole | 1448547-40-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 3-(biphenyl-3-yl)-2-(4-ethylphenyl)-1-methyl-1H-indole
• 英文别名: 2-(4-Ethylphenyl)-1-methyl-3-(3-phenylphenyl)indole；2-(4-ethylphenyl)-1-methyl-3-(3-phenylphenyl)indole
• CAS: 1448547-40-7
• 化学式: C₂₉H₂₅N
• 分子量: 387.524
• InChiKey: FYBKOZLVWBSIJH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  4.9
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  4-乙基苯硼酸 、 2,3-二溴-1-甲基吲哚 在 potassium phosphate 、 四(三苯基膦)钯 作用下， 以 1,4-二氧六环 为溶剂， 反应 14.17h， 生成 3-(biphenyl-3-yl)-2-(4-ethylphenyl)-1-methyl-1H-indole
  参考文献：
  名称：

  One-pot synthesis of arylated 1-methyl-1H-indoles by Suzuki–Miyaura cross-coupling reactions of 2,3-dibromo-1-methyl-1H-indole and 2,3,6-tribromo-1-methyl-1H-indole

  摘要：

  Arylated 1-methyl-1H-indoles were prepared by Suzuki-Miyaura cross-coupling reactions of 2,3-dibromo-1-methyl-1H-indole and 2,3,6-tribromo-1-methyl-1H-indole. The reactions proceed with very good regioselectivity in favour of position 2. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.05.100

文献信息

• One-pot synthesis of arylated 1-methyl-1H-indoles by Suzuki–Miyaura cross-coupling reactions of 2,3-dibromo-1-methyl-1H-indole and 2,3,6-tribromo-1-methyl-1H-indole
  作者：Muhammad Farooq Ibad、Dhafer Saber Zinad、Munawar Hussain、Asad Ali、Alexander Villinger、Peter Langer

  DOI：10.1016/j.tet.2013.05.100

  日期：2013.9

  Arylated 1-methyl-1H-indoles were prepared by Suzuki-Miyaura cross-coupling reactions of 2,3-dibromo-1-methyl-1H-indole and 2,3,6-tribromo-1-methyl-1H-indole. The reactions proceed with very good regioselectivity in favour of position 2. (C) 2013 Elsevier Ltd. All rights reserved.