5-[2-(2-fluorophenoxy)ethyl]-2,4-thiazolidinedione | 200631-97-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5-[2-(2-fluorophenoxy)ethyl]-2,4-thiazolidinedione
• 英文别名: 5-[2-(2-fluorophenoxy)ethyl]thiazolidine-2,4-dione；2,4-Thiazolidinedione, 5-[2-(2-fluorophenoxy)ethyl]-；5-[2-(2-fluorophenoxy)ethyl]-1,3-thiazolidine-2,4-dione
• CAS: 200631-97-6
• 化学式: C₁₁H₁₀FNO₃S
• 分子量: 255.27
• InChiKey: VVUWDCNUSNOQMQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  80.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF<br/>[FR] MIMETIQUES DU GLUCOCORTICOIDE, PROCEDES DE FABRICATION DE CES MIMETIQUES, COMPOSITIONS PHARMACEUTIQUES ET LEURS UTILISATIONS
  申请人：BOEHRINGER INGELHEIM PHARMA

  公开号：WO2003082787A1

  公开（公告）日：2003-10-09

  Compounds of Formula (IA) and Formula (IB) wherein R1, R2, R3, R4, R5, and R6 are as defined herein for Formula (IA) or Formula (IB), or a tautomer, prodrug, solvate,or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

  式（IA）和式（IB）的化合物，其中R1、R2、R3、R4、R5和R6如本说明所定义的适用于式（IA）或式（IB），或其互变异构体、前药、溶剂化合物或盐；含有这些化合物的药物组合物，以及利用这些化合物调节糖皮质激素受体功能的方法、治疗由糖皮质激素受体功能介导的疾病状态或病情特征或患者体内的炎症、过敏或增殖过程的方法。
• NOVEL THIAZOLIDONE-2 DERIVATIVES, 4-DIKETONE SUBSTITUTED, METHOD FOR OBTAINING THEM AND PHARMACEUTICAL COMPOSITONS CONTAINING SAME
  申请人：——

  公开号：US20010007875A1

  公开（公告）日：2001-07-12

  The present invention relates to the field of chemistry and more particularly to that of therapeutic chemistry. The subject of the present invention is more precisely new 5-phenoxyalkyl-2,4-thiazolidinediones of general formula I: 1 in which A represents a linear or branched alkylene group comprising from 2 to 16 carbon atoms D represents a homo- or heterocarbon mono-, di- or tricyclic aromatic structure which may include one or more heteroatoms X represents the substituent of the aromatic structure and is as defined in claim 1 n is an integer ranging from 1 to 3 with the proviso that if A represents a butyl radical, 2 does not represent the 4-chlorophenyl group. The invention also relates to the tautomeric forms, to the enantiomers, diastereoisomers and epimers of the compounds of general formula I, in free or salified form. The present invention also relates to the processes for producing the compounds of general formula I, their use as antidiabetic agents, and in the treatment of the metabolic syndrome of insulin resistance, as well as the pharmaceutical compositions which contain the compounds of general formula I.

  本发明涉及化学领域，更特别地涉及治疗化学领域。本发明的主题更准确地说是通式I的新5-苯氧烷基-2,4-噻唑烷二酮：其中A代表包含2至16个碳原子的直链或支链烷基基团，D代表可能包含一个或多个杂原子的同源或异源碳单元、双环或三环芳香结构，X代表芳香结构的取代基，如在权利要求中定义，n是一个介于1到3之间的整数，但如果A代表丁基基团，则2不代表4-氯苯基团。该发明还涉及通式I化合物的互变异构体、对映异构体和外消旋体，无论是自由形式还是盐化形式。本发明还涉及制备通式I化合物的方法，它们作为抗糖尿病药物的用途，以及在胰岛素抵抗代谢综合征的治疗中使用的含有通式I化合物的药物组合物。
• [EN] PHARMACEUTICAL COMPOSITION COMPRISING METFORMIN AND A 5-PHENOXYALKYL-2,4-THIAZOLIDINEDIONE-TYPE DERIVATIVE<br/>[FR] COMPOSITION PHARMACEUTIQUE COMPRENANT DE LA METFORMINE ET UN DERIVE DE TYPE 5-PHENOXYALKYLE-2,4-THIAZOLIDINEDIONE
  申请人：MERCK PATENT GMBH

  公开号：WO2002011721A1

  公开（公告）日：2002-02-14

  The present invention relates to a pharmaceutical composition comprising, as active ingredients, metformin optionally in the form of one of its pharmaceutically acceptable salts and a 5-phenoxyalkyl-2,4-thiazolidinedione-type derivative.

  本发明涉及一种药物组合物，包括作为活性成分的二甲双胍，可选地以其药学上可接受的盐之一的形式存在，以及一种5-苯氧烷基-2,4-噻唑烷二酮类衍生物。
• New substituted 2,4-thiazolidinedione derivatives, processes for producing them and pharmaceutical compositions containing them
  申请人：Merck Patent GmbH.

  公开号：US20030100587A1

  公开（公告）日：2003-05-29

  The present invention generally relates to a process for producing Compounds of formula I: 1 wherein D, X, A, and n are defined herein.

  本发明通常涉及一种生产式I化合物的方法：其中D，X，A和n在此定义。
• Pharmaceutical composition comprising metformin and a 5-phenoxyalkyl-2,4-thiazolidinedione-type derivative
  申请人：——

  公开号：US20040014797A1

  公开（公告）日：2004-01-22

  The present invention relates to a pharmaceutical composition comprising, as active ingredients, metformin optionally in the form of one of its pharmaceutically acceptable salts and a 5-phenoxyalkyl-2,4-thiazolidinedione-type derivative.

  本发明涉及一种制药组合物，包括作为活性成分的二甲双胍，可选地以其药学上可接受的盐的形式存在，以及一种5-苯氧基烷基-2,4-噻唑烷二酮类衍生物。