4-甲基-6-壬基-嘧啶-2-基胺 | 100878-30-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 4-甲基-6-壬基-嘧啶-2-基胺
• 英文名称: 4-methyl-6-nonyl-pyrimidin-2-ylamine
• CAS: 100878-30-6
• 化学式: C₁₄H₂₅N₃
• 分子量: 235.373
• InChiKey: LBNCSMOIWRKEBE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.66
• 重原子数：
  17.0
• 可旋转键数：
  8.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  51.8
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  4-甲基-6-壬基-嘧啶-2-基胺 、 对乙酰胺基苯磺酰氯 生成 N-acetyl-sulfanilic acid-(4-methyl-6-nonyl-pyrimidin-2-ylamide)
  参考文献：
  名称：

  Lateral Stability During Forward-Induced Stepping for Dynamic Balance Recovery in Young and Older Adults

  摘要：

  Background. Balance dysfunction related to lateral instability has been associated with falls and fall-related injuries among older individuals. Protective stepping for dynamic balance recovery requires the effective control of lateral body motion, This study investigated the relationship between aging, falls, and lateral stability during forward-induced stepping for dynamic balance recovery.Methods. Forward steps were induced by a motor-driven waist-pull system in 12 younger adults, 20 healthy community-dwelling older adult nonfallers, and IS older adults who had reported falls. Group differences in kinetic and kinematic stepping characteristics for a range of Postural disturbance magnitudes were evaluated.Results. Despite group similarities in anticipatory postural adjustments for minimizing lateral instability, the older fallers demonstrated significantly greater sideways body motion toward the stepping side at first-step foot contact and a more laterally directed foot placement. During the first step, forward-stepping characteristics were generally comparable between the groups, but the older falters had an earlier liftoff time and longer step duration.Conclusions. During forward-induced protective stepping, otherwise healthy older adults who had experienced falls showed particular differences in their control of lateral body motion that were not attributable to changes in anticipatory postural mechanisms. Aging changes in controlling lateral body motion during protective stepping appear to involve factors that intervene between the first-step liftoff and foot contact and/or adaptations in stepping patterns related to prior planning.

  DOI：

  10.1093/gerona/56.9.m589
• 作为产物：
  描述：

  2-十一酮 在 硫酸 作用下， 生成 4-甲基-6-壬基-嘧啶-2-基胺
  参考文献：
  名称：

  Lateral Stability During Forward-Induced Stepping for Dynamic Balance Recovery in Young and Older Adults

  摘要：

  Background. Balance dysfunction related to lateral instability has been associated with falls and fall-related injuries among older individuals. Protective stepping for dynamic balance recovery requires the effective control of lateral body motion, This study investigated the relationship between aging, falls, and lateral stability during forward-induced stepping for dynamic balance recovery.Methods. Forward steps were induced by a motor-driven waist-pull system in 12 younger adults, 20 healthy community-dwelling older adult nonfallers, and IS older adults who had reported falls. Group differences in kinetic and kinematic stepping characteristics for a range of Postural disturbance magnitudes were evaluated.Results. Despite group similarities in anticipatory postural adjustments for minimizing lateral instability, the older fallers demonstrated significantly greater sideways body motion toward the stepping side at first-step foot contact and a more laterally directed foot placement. During the first step, forward-stepping characteristics were generally comparable between the groups, but the older falters had an earlier liftoff time and longer step duration.Conclusions. During forward-induced protective stepping, otherwise healthy older adults who had experienced falls showed particular differences in their control of lateral body motion that were not attributable to changes in anticipatory postural mechanisms. Aging changes in controlling lateral body motion during protective stepping appear to involve factors that intervene between the first-step liftoff and foot contact and/or adaptations in stepping patterns related to prior planning.

  DOI：

  10.1093/gerona/56.9.m589