N-(trifluoromethoxy-benzyl)-4,5-dihydro-1H-imidazol-2-amine | 1198211-58-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N-(trifluoromethoxy-benzyl)-4,5-dihydro-1H-imidazol-2-amine
• 英文别名: N-(2-trifluoromethoxy-benzyl)-4,5-dihydro-1H-imidazol-2-amine；N-[[2-(trifluoromethoxy)phenyl]methyl]-4,5-dihydro-1H-imidazol-2-amine
• CAS: 1198211-58-3
• 化学式: C₁₁H₁₂F₃N₃O
• 分子量: 259.231
• InChiKey: JZHBZAULPDFTLR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  45.6
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS
  申请人：Fang Wenkui K.

  公开号：US20090306161A1

  公开（公告）日：2009-12-10

  Described herein are compounds for and methods of treating conditions or diseases in a subject by administering to the subject a pharmaceutical composition containing an effective amount of an α-adrenergic modulator. The compounds and methods are also useful for alleviating types of pain, both acute and chronic.

  本文描述了一种治疗受试者疾病或病症的化合物和方法，方法是通过向受试者施用含有有效量α-肾上腺素调节剂的药物组合物。这些化合物和方法还可用于缓解各种类型的疼痛，包括急性和慢性疼痛。
• Methods of treating alpha adrenergic mediated conditions
  申请人：ALLERGAN, INC.

  公开号：EP2377534A1

  公开（公告）日：2011-10-19

  Described herein are compounds for use in a method of treating a condition or disease in a subject by administering to the subject a pharmaceutical composition containing an effective amount of an α-adrenergic modulator. The compounds are also useful for alleviating types of pain, both acute and chronic.

  本文所描述的化合物可用于通过给受试者施用含有有效量的α-肾上腺素能调节剂的药物组合物来治疗受试者的病症或疾病的方法。这些化合物还可用于减轻急性和慢性疼痛。
• COMPOUND FOR TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS
  申请人：ALLERGAN, INC.

  公开号：EP2932968A1

  公开（公告）日：2015-10-21

  The present invention provides a compound represented by the following formula, or a pharmaceutically-acceptable salt or tautomer thereof: wherein R1 and R2 are independently selected from halogen and C1-4 halogenated alkyl. The compound is useful in the treatment of alpha adrenergic mediated conditions such as pain.

  本发明提供了由下式表示的化合物或其药学上可接受的盐或同系物： 其中 R1 和 R2 独立选自卤素和 C1-4 卤代烷基。该化合物可用于治疗α肾上腺素能介导的病症，如疼痛。
• METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS USING IMIDAZOLINE DERIVATIVES
  申请人：ALLERGAN, INC.

  公开号：EP2303264B1

  公开（公告）日：2018-04-04
• US8063231B2
  申请人：——

  公开号：US8063231B2

  公开（公告）日：2011-11-22