2-hydroxymethyl-4-isopropylphenol | 102359-72-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-hydroxymethyl-4-isopropylphenol
• 英文别名: 2-(Hydroxymethyl)-4-(propan-2-yl)phenol；2-(hydroxymethyl)-4-propan-2-ylphenol
• CAS: 102359-72-8
• 化学式: C₁₀H₁₄O₂
• 分子量: 166.22
• InChiKey: NQYJZVIUIWEHNX-UHFFFAOYSA-N

物化性质

• 沸点：
  289.6±25.0 °C(Predicted)
• 密度：
  1.095±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-hydroxymethyl-4-isopropylphenol 以 水 为溶剂， 生成 2,6-di-(2-hydroxy-5-isopropylbenzyl)-4-isopropylphenol
  参考文献：
  名称：

  Lamartine, Roger; Perrin, Robert; Vicens, Jacques, Molecular Crystals and Liquid Crystals (1969-1991), 1986, vol. 134, p. 219 - 236

  摘要：

  DOI：
• 作为产物：
  描述：

  聚合甲醛 、 4-异丙基苯酚 以 水 为溶剂， 生成 2-hydroxymethyl-4-isopropylphenol
  参考文献：
  名称：

  Lamartine, Roger; Perrin, Robert; Vicens, Jacques, Molecular Crystals and Liquid Crystals (1969-1991), 1986, vol. 134, p. 219 - 236

  摘要：

  DOI：

文献信息

• COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY
  申请人：CHIESI FARMACEUTICI S.p.A

  公开号：US20140161736A1

  公开（公告）日：2014-06-12

  Compounds of formula (I) described herein act both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists and are useful for the prevention and/or treatment of broncho-obstructive or inflammatory diseases.

  本文件中描述的公式(I)化合物既可作为毒蕈碱受体拮抗剂，也可作为β2肾上腺素能受体激动剂，并且用于预防或治疗支气管阻塞或炎症性疾病。
• QUATERNARY AMMONIUM SALT COMPOUNDS
  申请人：Mitsuyama Etsuko

  公开号：US20120046467A1

  公开（公告）日：2012-02-23

  [Problem] The object of the present invention is to provide a novel compound having 132 adrenergic receptor agonist activity and muscarinic receptor antagonist activity. [Means for Solving the Problem] The present invention is a quaternary ammonium salt compounds represented by formula (I), or a pharmaceutically acceptable salt thereof, with superior β32 adrenergic receptor agonist activity and muscarinic receptor antagonist activity.

  本发明的目的是提供一种具有132肾上腺素受体激动剂活性和肌制剂受体拮抗活性的新型化合物。本发明是一种由化学式(I)表示的季铵盐化合物，或其在药学上可接受的盐，具有优越的β32肾上腺素受体激动剂活性和肌制受体拮抗活性。
• Tawata, Shinkichi; Taira, Shigehiko; Kikizu, Hirofumi, Bioscience, Biotechnology and Biochemistry, 1997, vol. 61, # 12, p. 2103 - 2105
  作者：Tawata, Shinkichi、Taira, Shigehiko、Kikizu, Hirofumi、Kobamoto, Naotada、Ishihara, Masanobu、Toyama, Seizen

  DOI：——

  日期：——
• METHODS FOR FORMING A POLYCARBONATE WITH A HYDROPHILIC SURFACE
  申请人：GM GLOBAL TECHNOLOGY OPERATIONS LLC

  公开号：US20160264729A1

  公开（公告）日：2016-09-15

  In an example of a method disclosed herein, a polycarbonate with a hydrophilic surface is formed. An ether substituted dichlorosilane, phosgene, and a Bisphenol reactant are polymerized to form a polycarbonate including a hydrolyzable silane in its backbone chain. The hydrolyzable silane includes an alkoxy group attached to a silicon atom. The alkoxy group on the hydrolyzable silane is converted to a more hydrophilic functional group to form the polycarbonate with the hydrophilic surface.
• NITROGENOUS HETEROCYCLIC AMIDE DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL APPLICATION
  申请人：Sichuan Haisco Pharmaceutical Co., Ltd.

  公开号：US20210205291A1

  公开（公告）日：2021-07-08

  Provided are a compound represented by formula (I) or a stereoisomer, hydrate, metabolite, solvate, pharmaceutically acceptable salt, eutectic mixture, or prodrug thereof, and a preparation method thereof, and an application for preparing a pharmaceutical product for treating a disease related to obstructed airways, wherein each substituent in the compound represented by formula (I) is as described in the specification.