| 1354004-26-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 1354004-26-4
• 化学式: C₁₄H₁₀IN₃O
• 分子量: 363.157
• InChiKey: DKOOIEDDTMZOQS-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  、 2-(三甲基硅烷基)乙氧甲基氯 在 sodium hydride 、 potassium tert-butylate 作用下， 反应 1.08h， 以33%的产率得到5-Iodo-2-pyridin-3-yl-1-(2-trimethylsilylethoxymethyl)indole-3-carbonitrile
  参考文献：
  名称：

  Synthesis of 2,5-disubstituted-3-cyanoindoles

  摘要：

  An efficient synthesis of 2,5-disubstituted-3-cyanoindoles is described. This approach utilizes a highly selective iodination together with the modified Made lung reaction to generate an intermediate which can be readily transformed to more fully elaborated 2,5-disubstituted-3-cyanoindole templates that were previously difficult to access. Detailed examples and utility of this approach are presented herein. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.11.009