4-(甲基氨基)-3-硝基苯基苯基甲酮 | 66353-71-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-(甲基氨基)-3-硝基苯基苯基甲酮
• 英文名称: 4-benzoyl-N-methyl-2-nitroaniline
• 英文别名: 4-Methylamino-3-nitro-benzophenon；4-Benzoyl-2-nitro-N-methylanilin；4-methylamino-3-nitro-benzophenone；4-(methylamino)-3-nitrophenyl phenyl ketone；[4-(methylamino)-3-nitrophenyl]-phenylmethanone
• CAS: 66353-71-7
• 化学式: C₁₄H₁₂N₂O₃
• 分子量: 256.261
• InChiKey: FFJICZMWZQXOLC-UHFFFAOYSA-N

物化性质

• 溶解度：
  二氯甲烷；

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  74.9
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2922399090

反应信息

• 作为反应物：
  描述：

  4-(甲基氨基)-3-硝基苯基苯基甲酮 在 sodium hydroxide 作用下， 生成 4-羟基-3-硝基苯甲酮
  参考文献：
  名称：

  Abramovitch et al., Journal of the Chemical Society, 1957, p. 1781,1787

  摘要：

  DOI：
• 作为产物：
  描述：

  3-硝基-4-氯二苯甲酮 在 甲醇 、 乙醇 作用下， 生成 4-(甲基氨基)-3-硝基苯基苯基甲酮
  参考文献：
  名称：

  van Alphen, Recueil des Travaux Chimiques des Pays-Bas, 1930, vol. 49, p. 383,387

  摘要：

  DOI：

文献信息

• Benz-acylbenzimidazole-2-carboxylic acid derivatives
  申请人：Ciba-Geigy Corporation

  公开号：US04141982A1

  公开（公告）日：1979-02-27

  New heterocyclylcarboxylic acid derivatives which are acylated in the nucleus, especially benz-acyl-benzimidazole-2-carboxylic acid derivatives of the formula ##STR1## in which R is a free, esterified or amidated carboxyl group or a free, etherified or esterified hydroxymethyl group, R.sub.1 is an aliphatic, cycloaliphatic, aromatic, araliphatic, heterocyclic or heterocyclic-aliphatic radical, R.sub.2 is hydrogen or an aliphatic radical and Ph is a 1,2-phenylene group containing the radical R.sub.1 --C(.dbd.O)--, with the proviso that R.sub.1 contains at least 2 carbon atoms if Ph is otherwise unsubstituted, R.sub.2 is ethyl and R is acetoxymethyl, and salts of such compounds having salt-forming properties, are useful as anti-allergic agents.

  新的杂环羧酸衍生物在核内酰化，特别是公式为##STR1##的苯酰基苯并咪唑-2-羧酸衍生物，其中R是自由的、酯化的或酰胺化的羧基或自由的、醚化的或酯化的羟甲基基团，R.sub.1是脂肪烃、环脂烃、芳香烃、芳基烃、杂环烃或杂环-脂肪基团，R.sub.2是氢或脂肪基团，Ph是含有基团R.sub.1--C(.dbd.O)--的1,2-苯基基团，但R.sub.1至少含有2个碳原子，如果Ph是未取代的，R.sub.2是乙基，R是乙酰氧甲基，以及具有成盐性质的这类化合物的盐，可用作抗过敏剂。
• Acyl-benzimidazole-2-methanol derivatives
  申请人：Ciba-Geigy Corporation

  公开号：US04213993A1

  公开（公告）日：1980-07-22

  New heterocyclylcarboxylic acid derivatives which are acylated in the nucleus, especially benz-acyl-benzimidazole-2-carboxylic acid derivatives of the formula ##STR1## in which R is a free, esterified or amidated carboxyl group or a free, etherified or esterified hydroxymethyl group, R.sub.1 is an aliphatic, cycloaliphatic, aromatic, araliphatic, heterocyclic or heterocyclic-aliphatic radical, R.sub.2 is hydrogen or an aliphatic radical and Ph is a 1,2-phenylene group containing the radical R.sub.1 --C(.dbd.O)--, with the proviso that R.sub.1 contains at least 2 carbon atoms if Ph is otherwise unsubstituted, R.sub.2 is ethyl and R is acetoxymethyl, and salts of such compounds having salt-forming properties, are useful as anti-allergic agents.

  新的杂环羧酸衍生物在核内进行酰化，特别是公式为##STR1##的苯乙酰基苯并咪唑-2-羧酸衍生物，其中R是自由的、酯化的或酰胺化的羧基或自由的、醚化的或酯化的羟甲基基团，R.sub.1是脂肪族、环脂族、芳香族、芳基脂肪族、杂环族或杂环脂肪族基团，R.sub.2是氢或脂肪基团，Ph是包含基团R.sub.1 --C(.dbd.O)--的1,2-苯基烷基，但前提是如果Ph未被其他基团取代，R.sub.1至少包含2个碳原子，R.sub.2是乙基，R是乙酰氧甲基，以及具有成盐性质的这些化合物的盐，可用作抗过敏剂。
• Benz-acyl-benzimidazole derivatives and antiallergic compositions
  申请人：Ciba-Geigy Corporation

  公开号：US04344957A1

  公开（公告）日：1982-08-17

  New heterocyclylcarboxylic acid derivatives which are acylated in the nucleus, especially benz-acyl-benzimidazole-2-carboxylic acid derivatives of the formula ##STR1## in which R is a free, esterified or amidated carboxyl group or a free, etherified or esterified hydroxymethyl group, R.sub.1 is an aliphatic, cycloaliphatic, aromatic, araliphatic, heterocyclic or heterocyclic-aliphatic radical, R.sub.2 is hydrogen or an aliphatic radical and Ph is a 1,2-phenylene group containing the radical R.sub.1 --C(.dbd.O)--, with the proviso that R.sub.1 contains at least 2 carbon atoms if Ph is otherwise unsubstituted, R.sub.2 is ethyl and R is acetoxymethyl, and salts of such compounds having salt-forming properties, are useful as anti-allergic agents.

  新的杂环羧酸衍生物，在核内酰化，特别是公式为##STR1## 的苯乙酰基苯并咪唑-2-羧酸衍生物，其中R是自由的、酯化的或酰胺化的羧基或自由的、醚化的或酯化的羟甲基基团，R.sub.1是脂肪烃基、环状脂肪烃基、芳香族基、芳基脂肪基基团、杂环基或杂环-脂肪基基团，R.sub.2是氢或脂肪基，Ph是含有基团R.sub.1--C(.dbd.O)--的1,2-苯基基团，但前提是如果Ph未被其他基团取代，则R.sub.1至少含有2个碳原子，R.sub.2为乙基，R为乙酰氧甲基，以及具有盐形成性质的这种化合物的盐，可用作抗过敏剂。
• Synthesis and antiparasitic activity of albendazole and mebendazole analogues
  作者：Gabriel Navarrete-Vázquez、Lilián Yépez、Alicia Hernández-Campos、Amparo Tapia、Francisco Hernández-Luis、Roberto Cedillo、José González、Antonio Martı́nez-Fernández、Mercedes Martı́nez-Grueiro、Rafael Castillo

  DOI：10.1016/s0968-0896(03)00497-8

  日期：2003.10

  Albendazole (Abz) and Mebendazole (Mbz) analogues have been synthesized and in vitro tested against the protozoa Giardia lamblia, Trichomonas vaginalis and the helminths Trichinella spiralis and Caenorhabditis elegans. Results indicate that compounds 4a, 4b (Abz analogues), 12b and 20 (Mbz analogues) are as active as antiprotozoal agents as Metronidazole against G. lamblia. Compound 9 was 58 times more active than Abz against T. vaginalis. Compounds 8 and 4a also shown high activity against this protozoan. Compounds 4b and 5a were as active as Abz. None of the Mbz analogues showed activity against T. vaginalis. The anthelmintic activity presented by these compounds was poor. (C) 2003 Published by Elsevier Ltd.
• El-Hamouly; Abd-Allah; Tawfik, Egyptian Journal of Chemistry, 2004, vol. 47, # 3, p. 333 - 343
  作者：El-Hamouly、Abd-Allah、Tawfik

  DOI：——

  日期：——