肌苷-8-14C | 3926-71-4

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 中文名称: 肌苷-8-14C
• 英文名称: (-)-[8-14C]inosine
• 英文别名: <8-(14)C>inosine；inosine；Inosin-8-¹⁴C-1'-d；Inosine-8-14C；9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one
• CAS: 3926-71-4
• 化学式: C₁₀H₁₂N₄O₅
• 分子量: 270.218
• InChiKey: UGQMRVRMYYASKQ-USSWDBROSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  129
• 氢给体数：
  4
• 氢受体数：
  6

安全信息

• 危险品运输编号：
  UN 2910 7

反应信息

• 作为反应物：
  描述：

  肌苷-8-14C 在 Brevibacterium acetylicum ATCC₉₅₃ cell extract 、 5’-三磷酸腺苷 作用下， 反应 0.17h， 生成 Inosin-8-14C-5'-phosphat
  参考文献：
  名称：

  Development of an Improved Assay for Purine Nucleoside Kinase Activity in Cell Extracts and Detection of Inosine Kinase Activity inBrevibacterium acetylicumATCC 953, Related Species, andCorynebacterium flaccumfaciensATCC 6887

  摘要：

  An improved assay was developed to detect direct purine nucleoside phosphorylating activity in cell-free extracts. Direct inosine phosphorylating activity was detected in 2 of 70 species tested. Both activities, which depended on magnesium ion and ATP, phosphorylated a hydroxyl group at the 5′ position of inosine. The new assay was shown to be useful for screening of direct purine nucleoside phosphorylating activity and have the potential to detect inosine kinase in the presence of a background of nucleoside phosphorylase and purine phosphoribosyltransferase activities. Previously, the latter two activities made it difficult to correctly detect direct phosphorylation of inosine by inosine kinase.

  DOI：

  10.1271/bbb.64.761

文献信息

• Synthesis of isotopically labelled versions of adenosine agonist GR79236
  作者：Alan H. Wadsworth、John J. Newman、Mark D. Wipperman、Ian Fellows、Derek R. Sutherland

  DOI：10.1002/(sici)1099-1344(200001)43:1<11::aid-jlcr286>3.0.co;2-7

  日期：2000.1

  Versions of adenosine receptor agonist GR79236 (1), labelled either with carbon-14 (9) at C-8 of the purine ring or with tritium (15) in the cyclopentyl ring, were prepared in overall yields of 64% and 25% respectively. A mass labelled [M+4] version (24) containing carbon-13, nitrogen-15, and deuterium was also prepared in 3% yield. Copyright © 2000 John Wiley & Sons, Ltd.

  腺苷受体激动剂 GR79236 (1) 的版本，在嘌呤环的 C-8 上用碳 14 (9) 标记或在环戊基环中用氚 (15) 标记，分别以 64% 和 25% 的总产率制备. 还以 3% 的产率制备了含有碳 13、氮 15 和氘的质量标记为 [M+4] 版本 (24)。版权所有 © 2000 John Wiley & Sons, Ltd.