葡糖谷氨酸酯 | 113114-16-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 葡糖谷氨酸酯
• 英文名称: (2S)-2-amino-5-oxo-5-[(2R,3S,4R,5R)-3,4,5,6-tetrahydroxy-1-oxohexan-2-yl]oxypentanoic acid
• CAS: 113114-16-2
• 化学式: C₁₁H₁₉NO₉
• 分子量: 309.27
• InChiKey: JEYXXVGCDYHLSB-OXGAQCCNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.2
• 重原子数：
  21
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  188
• 氢给体数：
  6
• 氢受体数：
  10

文献信息

• BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF
  申请人：SENOMYX, INC.

  公开号：US20160376263A1

  公开（公告）日：2016-12-29

  The present invention includes compounds and compositions known to modify the perception of bitter taste, and combinations of said compositions and compounds with additional compositions, compounds, and products. Exemplary compositions comprise one or more of the following: cooling agents; inactive drug ingredients; active pharmaceutical ingredients; food additives or foodstuffs; flavorants, or flavor enhancers; food or beverage products; bitter compounds; sweeteners; bitterants; sour flavorants; salty flavorants; umami flavorants; plant or animal products; compounds known to be used in pet care products; compounds known to be used in personal care products; compounds known to be used in home products; pharmaceutical preparations; topical preparations; cannabis-derived or cannabis-related products; compounds known to be used in oral care products; beverages; scents, perfumes, or odorants; compounds known to be used in consumer products; silicone compounds; abrasives; surfactants; warming agents; smoking articles; fats, oils, or emulsions; and/or probiotic bacteria or supplements.

  本发明涵盖已知用于改变苦味感知的化合物和组合物，以及所述组合物和化合物与额外的组合物、化合物和产品的组合。示例组合物包括以下一种或多种：冷却剂；无活性药物成分；活性药用成分；食品添加剂或食品；调味剂或调味增强剂；食品或饮料产品；苦味化合物；甜味剂；苦味剂；酸味调味剂；咸味调味剂；鲜味调味剂；植物或动物产品；已知用于宠物护理产品中的化合物；已知用于个人护理产品中的化合物；已知用于家用产品中的化合物；制药制剂；局部制剂；大麻衍生或与大麻相关的产品；已知用于口腔护理产品中的化合物；饮料；香味、香水或除臭剂；已知用于消费品中的化合物；硅化合物；磨料；表面活性剂；发热剂；吸烟物品；脂肪、油脂或乳化剂；和/或益生菌或补充剂。
• Topical and oral formulations of cardiac glycosides for treating skin diseases
  申请人：Streeper Robert

  公开号：US20060205679A1

  公开（公告）日：2006-09-14

  The present invention provides method, preparation and use of a variety of pharmaceutical compositions containing at least one digitalis glycoside such as oleandrin, odoroside-A, neriifolin, proscillaridin-A, methyl-proscillaridin-A, digitoxin, digoxin alone or at least one digitalis glycoside complexed with cyclodextrins. In another aspect, the present invention provides an effective method to treat diseases in mammals. In yet another aspect, the present invention provides an effective method for treating skin diseases in a human or non-human animal.

  本发明提供了一种方法、制备和使用多种含有至少一种毛地黄苷类药物成分的药物组合物，例如奥利安定、奥多罗苷A、内里福林、普罗斯西拉里丁A、甲基普罗斯西拉里丁A、地高辛、地高辛或至少一种毛地黄苷类与环糊精络合的药物。另一方面，本发明提供了一种有效的方法来治疗哺乳动物的疾病。另一方面，本发明提供了一种有效的方法来治疗人类或非人类动物的皮肤疾病。
• [EN] PERSONAL CARE COMPOSITIONS COMPRISING ZINC:USNIC ACID COMPLEXES AND METHODS OF USE<br/>[FR] COMPOSITIONS DE SOINS PERSONNELS COMPRENANT DES COMPLEXES ZINC : ACIDE USNIQUE ET PROCÉDÉS D'UTILISATION CORRESPONDANTS
  申请人：COLGATE PALMOLIVE CO

  公开号：WO2019018287A1

  公开（公告）日：2019-01-24

  Disclosed herein are personal care compositions comprising Zn:usnate complexes having a 1:2 zinc to usnate molar ratio. Methods of making and using the compositions are also provided. The personal care compositions may include a cleansing component and an antibacterial component, wherein the antibacterial component comprises Zn:usnate complexes having a 1:2 zinc to usnate molar ratio.

  本文披露了含有1:2锌：乌酸盐复合物的个人护理组合物，方法包括制备和使用这些组合物。个人护理组合物可能包括清洁成分和抗菌成分，其中抗菌成分包括具有1:2锌：乌酸盐摩尔比的Zn:usnate复合物。
• COMPOUNDS USEFUL AS MODULATORS OF TRPM8
  申请人：Senomyx, Inc.

  公开号：US20170096418A1

  公开（公告）日：2017-04-06

  The present disclosure relates to compounds which are useful as cooling sensation compounds.

  本公开涉及作为冷感化合物有用的化合物。
• Low molecular weight ampholytic polymers for personal care applications
  申请人：Sabelko J. Jobiah

  公开号：US20070207106A1

  公开（公告）日：2007-09-06

  A cosmetically acceptable composition comprising from about 0.1 to about 10 weight percent, based on polymer solids, of a water-soluble ampholyte polymer comprising: from at least 1 to as much as 95 weight percent of the nonionic monomer acrylamide; from at least 5 to as much as 80 weight percent of the cationic monomer dimethyldiallylammonium chloride; from at least 1 to as much as 75 weight percent of the anionic monomer acrylic acid, is disclosed. The application of these polymers to a keratinous substance is also disclosed. In addition, a method of treating a keratinous substance comprising applying a cosmetically acceptable composition comprising from about 0.1 to about 10 weight percent, based on polymer solids, of an ampholyte polymer produced by the following process: (1) preparing a monomer solution containing: from at least 1 to as much as 95 weight percent of the nonionic monomer acrylamide; from at least 5 to as much as 80 weight percent of the cationic monomer dimethyldiallylammonium chloride; from at least 1 to as much as 75 weight percent of the anionic monomer acrylic acid; (2) providing a reactor and water to said reactor; (3) optionally charging said reactor with a sequestering agent, a chain transfer agent or a combination thereof; (3) purging said reactor to remove oxygen from said reactor; (4) heating the contents of said reactor; and (5) feeding said monomer solution and initiator solution into said reactor, is disclosed.

  一种化妆品可接受的组合物包括约0.1至约10重量百分比，基于聚合物固体计算，的水溶性两性离子聚合物，包括：至少1至高达95重量百分比的非离子单体丙烯酰胺；至少5至高达80重量百分比的阳离子单体二甲基二烯丙基氯化铵；至少1至高达75重量百分比的阴离子单体丙烯酸。还披露了将这些聚合物应用于角蛋白物质的方法。此外，还披露了一种治疗角蛋白物质的方法，包括施用包括约0.1至约10重量百分比，基于聚合物固体计算，的两性离子聚合物的化妆品可接受的组合物，该两性离子聚合物是通过以下过程制备的：（1）制备含有以下单体的单体溶液：至少1至高达95重量百分比的非离子单体丙烯酰胺；至少5至高达80重量百分比的阳离子单体二甲基二烯丙基氯化铵；至少1至高达75重量百分比的阴离子单体丙烯酸；（2）提供反应器和水给该反应器；（3）可选择地向反应器充入螯合剂、链转移剂或二者的组合物；（3）净化反应器以去除反应器中的氧气；（4）加热反应器的内容物；以及（5）将单体溶液和引发剂溶液注入反应器。