2-(biphenyl-4-sulfonyl)-2-methylpropionic acid ethyl ester | 1004770-43-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(biphenyl-4-sulfonyl)-2-methylpropionic acid ethyl ester
• 英文别名: 2-(biphenyl-4-sulfonyl)-2-methyl-propionic acid ethyl ester；Ethyl 2-methyl-2-(4-phenylphenyl)sulfonylpropanoate
• CAS: 1004770-43-7
• 化学式: C₁₈H₂₀O₄S
• 分子量: 332.42
• InChiKey: MOPXLRIOBYQLAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  68.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(biphenyl-4-sulfonyl)-2-methylpropionic acid ethyl ester 在 sodium hydroxide 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 1.5h， 以62%的产率得到2-(biphenyl-4-sulfonyl)-2-methylpropionic acid sodium salt
  参考文献：
  名称：

  Discovery of Small-Molecule Inhibitors of the ATPase Activity of Human Papillomavirus E1 Helicase

  摘要：

  The Boehringer Ingelheim compound collection was screened for inhibitors of the ATPase activity of human papillomavirus El helicase to develop antiviral agents that inhibit human papillomavirus (HPV) DNA replication. This screen led to the discovery of (biphenyl-4-sulfonyl)acetic acid 1, which inhibits the ATPase activity of HPV type 6 E1 helicase with a low micromolar IC50 value. A hit-to-lead exercise rapidly converted 1 into a low nanomolar lead series.

  DOI：

  10.1021/jm034206x
• 作为产物：
  描述：

  对联苯磺酰氯 、 alkaline earth salt of/the/ methylsulfuric acid 在 吡啶 、 sodium hydroxide 、 sodium sulfite 作用下， 以 二甲基亚砜 为溶剂， 反应 0.25h， 生成 2-(biphenyl-4-sulfonyl)-2-methylpropionic acid ethyl ester
  参考文献：
  名称：

  Discovery of Small-Molecule Inhibitors of the ATPase Activity of Human Papillomavirus E1 Helicase

  摘要：

  The Boehringer Ingelheim compound collection was screened for inhibitors of the ATPase activity of human papillomavirus El helicase to develop antiviral agents that inhibit human papillomavirus (HPV) DNA replication. This screen led to the discovery of (biphenyl-4-sulfonyl)acetic acid 1, which inhibits the ATPase activity of HPV type 6 E1 helicase with a low micromolar IC50 value. A hit-to-lead exercise rapidly converted 1 into a low nanomolar lead series.

  DOI：

  10.1021/jm034206x

文献信息

• Compounds Which Modulate The CB2 Receptor
  申请人：BERRY Angela

  公开号：US20080039464A1

  公开（公告）日：2008-02-14

  Compound of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.

  本发明揭示了化合物的公式（I）。根据本发明的化合物与CB2受体结合，并且是激动剂、拮抗剂或逆激动剂，适用于治疗炎症。那些是激动剂的化合物还可用于治疗疼痛。
• Compounds Which Modulate the CB2 Receptor
  申请人：BERRY Angela

  公开号：US20110071127A1

  公开（公告）日：2011-03-24

  Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.

  公式(I)的化合物被披露。本发明的化合物与CB2受体结合，并且是激动剂、拮抗剂或反向激动剂，可用于治疗炎症。那些是激动剂的化合物还可用于治疗疼痛。
• SULFONYL COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP2081905B1

  公开（公告）日：2012-09-12
• US7935715B2
  申请人：——

  公开号：US7935715B2

  公开（公告）日：2011-05-03
• US8299111B2
  申请人：——

  公开号：US8299111B2

  公开（公告）日：2012-10-30