N-ethylstearamide | 29878-14-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-ethylstearamide
• 英文别名: N-Ethyl-octadecanamid；Stearoylaethylamin；Stearinsaeure-aethylamid；N-Aethyl-stearamid；N-ethyloctadecanamide
• CAS: 29878-14-6
• 化学式: C₂₀H₄₁NO
• 分子量: 311.552
• InChiKey: VLYFHHYLZLDEIU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.3
• 重原子数：
  22
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-ethylstearamide 在 五氯化磷 、 水 作用下， 生成 2,2-二氯-十八烷酸乙基酰胺
  参考文献：
  名称：

  v.Braun; Jostes; Muench, Justus Liebigs Annalen der Chemie, 1927, vol. 453, p. 134

  摘要：

  DOI：

文献信息

• PROCESS FOR ALKENYLATING CARBOXAMIDES
  申请人：Staffel Wolfgang

  公开号：US20090131657A1

  公开（公告）日：2009-05-21

  The present invention relates to a process for preparing N-(1-alkenyl)carboxamides of the formula I, which comprises reacting a carboxamide of the formula II with an alkyne of the formula III in the presence of a catalyst selected from among carbonyl complexes, halides and oxides of rhenium, manganese, tungsten, molybdenum, chromium and iron.

  本发明涉及一种制备式I的N-(1-烯基)羧酰胺的方法，包括在选择自铼、锰、钨、钼、铬和铁的羰基配合物、卤化物和氧化物之一作为催化剂的情况下，将式II的羧酰胺与式III的炔烃反应。
• Method for producing organic compounds by substituting halogen atoms
  申请人：MITSUI CHEMICALS, INC.

  公开号：EP1486479A1

  公开（公告）日：2004-12-15

  The invention pertains to a method in which a halogen atom of an organic compound is replaced with a group derived from a nucleophilic agent, at high yield and high efficiency, by the following method which includes a step of reacting the nucleophilic agent with an organic material having a halogen atom bonded to a carbon atom having four σ bonds, more specifically: a method for producing an organic compound having Q, the method including a step of reacting a compound represented by general formula (2) with an organic starting material having at least one halogen atom bonded to a carbon atom having four σ bonds so as to replace the halogen atom in the organic starting material with Q:         MQa     (2) (wherein M represents an alkali metal atom, an alkali earth metal atom, or a rare earth metal atom; Q represents a moiety of an inorganic acid or an active hydrogen compound derived by eliminating a proton, wherein Q is a halogen atom different from the halogen atom in the organic starting material having the halogen atom bonded to the carbon atom having the four σ bonds; and a represents an integer of 1 to 3) in the presence of a compound represented by general formula (1) (wherein Z- represents an anion derived by eliminating a proton from an inorganic acid or an active hydrogen compound; R2 is the same or different; R2 each independently represent a C1-C10 hydrocarbon group or two R2 on the same nitrogen atom may be bonded with each other to form a ring with the nitrogen atom).

  这项发明涉及一种方法，其中有机化合物中的卤素原子被来自亲核试剂的基团取代，且产率高效率高，通过以下方法实现，包括以下步骤：将亲核试剂与具有与碳原子形成四个σ键的卤素原子相结合的有机材料反应的步骤，更具体地说：一种用于生产具有Q的有机化合物的方法，包括以下步骤：将由通式（2）表示的化合物与至少一个卤素原子与碳原子形成四个σ键的有机起始材料反应，以将有机起始材料中的卤素原子替换为Q：         MQa     (2) （其中M代表碱金属原子、碱土金属原子或稀土金属原子；Q代表由消除质子衍生的无机酸或活性氢化合物的基团，其中Q是不同于有机起始材料中卤素原子的卤素原子，该卤素原子与具有四个σ键的碳原子相结合；a表示1到3的整数），在通式（1）表示的化合物的存在下 （其中Z-代表由无机酸或活性氢化合物中消除质子衍生的阴离子；R2相同或不同；R2各自独立地表示C1-C10烃基，或者两个R2在同一氮原子上可能与彼此结合形成与氮原子的环）。
• PROCESS FOR PRODUCING NITROGEN-CONTAINING COMPOUNDS
  申请人：Terasaka Michio

  公开号：US20100179349A1

  公开（公告）日：2010-07-15

  The present invention relates to a process for producing a tertiary amine by reducing an amide compound in the presence of a catalyst containing a sponge copper catalyst obtained by leaching alloy particles containing copper and aluminum and drying the thus leached alloy particles. The present invention provides a process for producing high-purity aliphatic tertiary amines containing a less amount of by-products at a high yield by subjecting aliphatic acid amides to hydrogenation reduction under solvent-free moderate conditions.

  本发明涉及一种在存在含有海绵铜催化剂的催化剂的情况下，通过还原酰胺化合物来生产三级胺的方法，所述海绵铜催化剂是通过浸出含有铜和铝的合金颗粒并干燥浸出的合金颗粒获得的。本发明提供了一种在无溶剂适度条件下将脂肪酸酰胺经过加氢还原处理以高产率产生含有少量副产物的高纯度脂肪族三级胺的方法。
• A METHOD OF TREATING PERIPHERAL INFLAMMATORY DISEASE
  申请人：Dublin City University

  公开号：EP3095444A1

  公开（公告）日：2016-11-23

  An active for use in the treatment or inhibition of an inflammatory disease associated with over-activation of Toll-like Receptor 4 (TLR4), Toll-like Receptor 2 (TLR2) and Myeloid differentiating protein 88 (Myd88) adaptor-like protein (Mal) while maintaining a subject's ability to respond normally to a pathogen, in which the active is an oleamide or a derivative thereof.

  一种用于治疗或抑制与Toll样受体4（TLR4）、Toll样受体2（TLR2）和髓样分化蛋白88（Myd88）适配样蛋白（Mal）过度激活相关的炎症性疾病，并同时保持受试者对病原体正常反应能力的活性物质为油酰胺或其衍生物。
• Guanidinoglycoside-mediated liposome-based delivery of therapeutics
  申请人：The Regents of the University of California

  公开号：US20180086782A1

  公开（公告）日：2018-03-29

  This disclosure relates to the incorporation of amphiphilic guanidinylated aminoglycosides (e.g., neomycin) into liposomal assemblies, which contain entrapped therapeutics. The lysosome is responsible for enzymatically breaking down and recycling large biomolecules and aged organelles. While malfunctioned lysosomal enzymes have been established in Lysosomal Storage Disorders (LSDs), recent reports have suggested that defects in lysosomal enzymes (e.g., glucocerebrosidase) are also linked to other chronic ailments, including neurological disorders such as Parkinson's Disease and related disorders.

  本公开涉及将两性亲和性胍基化氨基糖苷（例如新霉素）纳入含有封闭治疗剂的脂质体聚集体中。溶酶体负责酶解和回收大分子生物分子和老化的细胞器。虽然已经确定溶酶体酶在溶酶体贮积病（LSDs）中存在故障，但最近的报告表明，溶酶体酶（例如葡萄糖鞘脂酶）的缺陷也与其他慢性疾病有关，包括神经疾病如帕金森病及相关疾病。