(S)-4-[(S)-2-(3,4-difluoro-phenoxy)-butyl]-4,5-dihydro-oxazol-2-ylamine | 1205641-46-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (S)-4-[(S)-2-(3,4-difluoro-phenoxy)-butyl]-4,5-dihydro-oxazol-2-ylamine
• 英文别名: (4S)-4-[(2S)-2-(3,4-difluorophenoxy)butyl]-4,5-dihydro-1,3-oxazol-2-amine
• CAS: 1205641-46-8
• 化学式: C₁₃H₁₆F₂N₂O₂
• 分子量: 270.279
• InChiKey: CRDLPABGEBZORP-IUCAKERBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  56.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• 4,5-DIHYDRO-OXAZOL-2YL DERIVATIVES
  申请人：Galley Guido

  公开号：US20100029589A1

  公开（公告）日：2010-02-04

  The invention relates to compounds of formula I wherein R 1 , R 2 , X, Y, and n are defined in the specification and to pharmaceutically acceptable acid addition salts thereof. The invention also provides pharmaceutical compositions and methods of manufacture of such compounds. The compounds are useful for the treatment of diseases related to the biological function of the trace amine associated receptors, which diseases are depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders, schizophrenia, neurological diseases, Parkinson's disease, neurodegenerative disorders, Alzheimer's disease, epilepsy, migraine, substance abuse and metabolic disorders, eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.

  该发明涉及公式I的化合物，其中R1、R2、X、Y和n在规范中定义，并且其药学上可接受的酸盐。该发明还提供了制备这种化合物的药物组合物和方法。这些化合物可用于治疗与痕量胺相关受体的生物功能相关的疾病，这些疾病包括抑郁症、焦虑症、躁郁症、注意缺陷多动障碍、与压力有关的疾病、精神疾病、精神分裂症、神经系统疾病、帕金森病、神经退行性疾病、阿尔茨海默病、癫痫、偏头痛、物质滥用和代谢紊乱、进食障碍、糖尿病、糖尿病并发症、肥胖症、脂质代谢异常、能量消耗和吸收异常、体温稳态异常、睡眠和昼夜节律异常、心血管疾病。
• Aroma Composition to Reduce or Suppress Undesirable Bitter and Astringent Taste Impressions of Sweeteners
  申请人：Riess Thomas

  公开号：US20100151055A1

  公开（公告）日：2010-06-17

  The invention concerns an aroma composition to reduce or suppress a bitter or astringent impression in the oral cavity, comprising (i) one or more sweeteners and (ii) one or more specific bitter-masking aroma substances and/or flavourings and optionally (iii) one or more sweetness intensifying aroma substances and/or sweeteners and optionally (iv) one or more inactive substances or carriers. The invention also concerns a preparation, containing such an aroma composition, the use of an aroma composition for reducing or eliminating a bitter and astringent effect of an artificial sweetener and a corresponding method for reducing or eliminating the bitter and astringent effect of a sweetener.

  本发明涉及一种香气组合物，用于减少或抑制口腔中的苦涩或涩感，包括（i）一种或多种甜味剂和（ii）一种或多种特定的苦味掩蔽香气物质和/或调味料，以及可选的（iii）一种或多种增强甜味的香气物质和/或甜味剂，以及可选的（iv）一种或多种不活性物质或载体。本发明还涉及一种制剂，包含这样的香气组合物，使用香气组合物来减少或消除人工甜味剂的苦涩和涩感效果以及相应的方法。
• Compounds and mixtures influencing inflammatory states
  申请人：Symrise AG

  公开号：EP2633886A1

  公开（公告）日：2013-09-04

  Suggested is a compound of the formula (X) or any salt of a compound of the formula (X) or any mixture containing or consisting of two or more different compounds of the formula (X), two or more different salts of compounds of the formula (X) or one or more different compounds of the formula (X) and one or more different salts of compounds of the formula (X), wherein for R1, R2 and R3 independently of one another in every compound of the formula (X) the following applies: R1 means hydrogen or methyl, R2 means an organic residue with 5 carbon atoms and one oxygen atom or none and R3 means an organic residue with 10 carbon atoms and one or more oxygen atoms, or R1 and R2 together with the carbon atoms in positions 4 and 5 and the oxygen atom bound to the carbon atom in position 4 form a ring and comprise 5 carbon atoms and one oxygen atom or none, and R3 means an organic residue with 10 carbon atoms and one or more oxygen atoms, for use in a method for the prophylaxis and/or treatment of inflammation.

  建议采用式（X）化合物 或式 (X) 化合物的任何盐，或含有或由两种或两种以上不同的式 (X) 化合物、两种或两种以上不同的式 (X) 化合物的盐或一种或一种以上不同的式 (X) 化合物和一种或一种以上不同的式 (X) 化合物的盐组成的任何混合物，其中对于 在每个式 (X) 化合物中，相互独立的 R1、R2 和 R3 适用以下条件： R1 指氢或甲基、 R2 指具有 5 个碳原子和 1 个氧原子或无氧原子的有机残基，以及 R3 指具有 10 个碳原子和一个或多个氧原子的有机残基、 或 R1 和 R2 连同位于第 4 和第 5 位的碳原子以及与位于第 4 位的碳原子结合的氧原子形成一个环，由 5 个碳原子和 1 个氧原子或无碳原子组成，以及 R3 指具有 10 个碳原子和一个或多个氧原子的有机残基、 用于预防和/或治疗炎症的方法。
• Polyurea capsule compositions
  申请人：INTERNATIONAL FLAVORS & FRAGRANCES INC.

  公开号：US10085925B2

  公开（公告）日：2018-10-02

  A microcapsule composition useful in delivering an active material contains a first microcapsule and a second microcapsule. The first microcapsule has a zeta potential of 10 mV or greater, the second microcapsule has a zeta potential of 5 mV or less, and the weight ratio of the first microcapsule and the second microcapsule is between 1:10 and 10:1. Also disclosed are consumer products containing such a microcapsule composition.

  一种用于输送活性物质的微胶囊组合物含有第一种微胶囊和第二种微胶囊。第一种微胶囊的 zeta 电位为 10 mV 或更高，第二种微胶囊的 zeta 电位为 5 mV 或更低，第一种微胶囊和第二种微胶囊的重量比在 1:10 和 10:1 之间。还公开了含有这种微胶囊组合物的消费品。
• Compositions containing microcapsules coated with deposition proteins
  申请人：International Flavors & Fragrances Inc.

  公开号：US10695272B2

  公开（公告）日：2020-06-30

  A microcapsule composition containing microcapsules coated with a deposition protein, e.g., a protein-silanol copolymer, a protein-silane copolymer, a protein-siloxane copolymer, or a cationically modified protein, is provided as is a method for making the microcapsule composition and using the microcapsule composition in consumer products, in particular rinse-off consumer product.

  提供了一种微胶囊组合物，其中含有涂有沉积蛋白（如蛋白质-硅醇共聚物、蛋白质-硅烷共聚物、蛋白质-硅氧烷共聚物或阳离子改性蛋白质）的微胶囊，还提供了一种制造微胶囊组合物的方法，以及将微胶囊组合物用于消费品，特别是冲洗型消费品的方法。