4-(2-Aminoethyl)pyrrolidin-2-one hydrochloride | 1955553-31-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-(2-Aminoethyl)pyrrolidin-2-one hydrochloride
• 英文别名: 4-(2-aminoethyl)pyrrolidin-2-one;hydrochloride
• CAS: 1955553-31-7
• 化学式: C6H13ClN2O
• 分子量: 164.63
• InChiKey: PBUQCWVYVMDXKU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.11
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  55.1
• 氢给体数：
  3
• 氢受体数：
  2

文献信息

• 6-HETEROARYLOXY- AND 6-ARYLOXY-QUINOLINE-2-CARBOXAMIDES AND USES THEREOF
  申请人：AbbVie Inc.

  公开号：EP3102569A1

  公开（公告）日：2016-12-14
• [EN] 6-HETEROARYLOXY- AND 6-ARYLOXY-QUINOLINE-2-CARBOXAMIDES AND USES THEREOF<br/>[FR] 6-HÉTÉROARYLOXY- ET 6-ARYLOXY-QUINOLÉINE-2-CARBOXAMIDES ET LEURS UTILISATIONS
  申请人：ABBVIE INC

  公开号：WO2015119998A1

  公开（公告）日：2015-08-13

  Compounds of formula (I) and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein R1, R2, and R3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by voltage-gated sodium channels, e.g., Nav1.7 and/or Nav1.8. Methods for making the compounds are disclosed. Also disclosed are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.