N-(4-aminobutyl)aspartic acid | 262599-62-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(4-aminobutyl)aspartic acid
• 英文别名: AspIDA；2-(4-Aminobutylamino)butanedioic acid
• CAS: 262599-62-2
• 化学式: C₈H₁₆N₂O₄
• 分子量: 204.226
• InChiKey: JEGAPNXTUBSOQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.9
• 重原子数：
  14
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  113
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  在 盐酸 作用下， 以 水 为溶剂， 反应 2.0h， 生成 N-(4-aminobutyl)aspartic acid
  参考文献：
  名称：

  Gallium metal affinity capture tandem mass spectrometry for the selective detection of phosphopeptides in complex mixtures

  摘要：

  在一项关于赖氨酸衍生的三硝基乙酸（Nα, Nα-bis-(carboxymethyl)lysine, LysNTA）和天冬氨酸相关的亚氨基二乙酸（N-(4-aminobutyl)aspartic acid, AspIDA）作为选择性磷酸肽检测试剂的比较研究中，对金属亲和捕获串联质谱（MAC-MSMS）进行了评估。LysNTA 和 AspIDA 在溶液中与 GaIII 和磷酸化氨基酸及磷酸肽混合后会自发形成三元复合物。电喷雾产生的正复合离子的碰撞诱导解离会产生常见的碎片 (LysNTA + H)+ 或 (AspIDA + H)+ ，其 m/z 分别为 263 和 205。使用这些片段作为报告离子进行 MSMS 前体扫描，可以选择性地检测混合物中磷酸肽的多种电荷状态。从这项比较研究中可以看出，LysNTA 在检测磷酸肽方面优于 AspIDA，这可能是因为前者的配位数更高，GaIII-磷酸肽复合物的稳定常数更大。在继续开发用于蛋白质组学应用的 MAC-MSMS 的过程中，我们展示了其在柱后反应形式中的实用性。利用简单的柱后反应 "T "和注射泵输送我们的螯合试剂，可以从含有两倍摩尔过量牛血清白蛋白的溶液中选择性地分析α-酪蛋白胰蛋白磷酸肽。研究表明，MAC-MSMS 方法优于常用的中性磷酸损失扫描法。Copyright © 2008 John Wiley & Sons, Ltd. All Rights Reserved.

  DOI：

  10.1002/jms.1387

文献信息

• [EN] EPOXYEICOSATRIENOIC ACID ANALOGS AND METHODS OF MAKING AND USING THE SAME<br/>[FR] ANALOGUES DE L'ACIDE ÉPOXYÉICOSATRIÉNOÏQUE ET LEURS PROCÉDÉS DE FABRICATION ET D'UTILISATION
  申请人：MCW RES FOUND INC

  公开号：WO2012138706A1

  公开（公告）日：2012-10-11

  Compounds and compositions comprising epoxyeicosatrienoic acid (EET) analogs that act as EET agonists and are useful as medications in the treatment of drug-induced nephrotoxicity, hypertension and other related conditions. Methods of making and using the compounds and compositions are further described.

  含有环氧三烯酸（EET）类似物的化合物和组合物，其作为EET激动剂，并且在治疗药物诱导的肾毒性、高血压和其他相关疾病方面有用。进一步描述了制备和使用这些化合物和组合物的方法。
• POLYMER, PROCESS AND COMPOSITION
  申请人：Friederichs Joseph Petronella

  公开号：US20130211003A1

  公开（公告）日：2013-08-15

  There is described a process for producing a gel free hyperbranched polyamide polymer having primary amino groups (useful as a crosslinker). The process comprises the step of reacting at least one diamine and at least one unsaturated diester in a molar ratio of diamine to diester greater than 1 but less than 3 (preferably 2.1 to 2.9); to form the polyamide in a two stage reaction Michael addition and then amidation. The diamine in kept in excess with at least 5% of water by total weight of the diamine and diester, a reaction temperature less than the boiling point of the diamine; and is held under reduced pressure (30 mbar to 1 atms). Gelation does not occur even after substantially all ethylenic (—C═C—) double bonds; and >95% ester [—C(O)═O] groups have reacted. This violates the Flory rules which predict a gel would form based on the number of functional groups present and their degree of conversion.
• US9296860B2
  申请人：——

  公开号：US9296860B2

  公开（公告）日：2016-03-29
• [EN] POLYMER, PROCESS AND COMPOSITION<br/>[FR] POLYMÈRE, PROCÉDÉ ET COMPOSITION
  申请人：DSM IP ASSETS BV

  公开号：WO2011076785A1

  公开（公告）日：2011-06-30

  There is described a process for producing a gel free hyperbranched polyamide polymer having primary amino groups (useful as a crosslinker). The process comprises the step of reacting at least one diamine and at least one unsaturated diester in a molar ratio of diamine to diester greater than 1 but less than 3 (preferably 2.1 to 2.9); to form the polyamide in a two stage reaction Michael addition and then amidation. The diamine in kept in excess with at least 5% of water by total weight of the diamine and diester, a reaction temperature less than the boiling point of the diamine; and is held under reduced pressure (30 mbar to 1 atms). Gelation does not occur even after substantially all ethylenic (-C=C- ) double bonds; and >95% ester [-C(O)=O] groups have reacted. This violates the Flory rules which predict a gel would form based on the number of functional groups present and their degree of conversion.