4-(dodecylcarbamoyl)-2-nitrobenzyl (4-nitrophenyl) carbonate | 1018856-57-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(dodecylcarbamoyl)-2-nitrobenzyl (4-nitrophenyl) carbonate
• CAS: 1018856-57-9
• 化学式: C₂₇H₃₅N₃O₈
• 分子量: 529.59
• InChiKey: WZHPRHZKZKIXJL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.87
• 重原子数：
  38.0
• 可旋转键数：
  17.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  150.91
• 氢给体数：
  1.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  、 4-(dodecylcarbamoyl)-2-nitrobenzyl (4-nitrophenyl) carbonate 在 4-二甲氨基吡啶 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Constrained and UV-activatable cell-penetrating peptides for intracellular delivery of liposomes

  摘要：

  Herein we report on the development of a novel method of constraining a cell-penetrating peptide, which can be used to trigger transport of liposomes into cells upon in this case radiation with UV-light. A cell-penetrating peptide, which was modified on both termini with an alkyl chain, was anchored to the liposomal surface in a constrained and deactivated form. Since one of the two alkyl chains was connected to the peptide via a UV-cleavable linker, disconnection of this alkyl chain upon irradiation led to the exposure of the cell-penetrating peptide, and mediated the transport of the entire liposome particle into cells. (C) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jconrel.2012.10.008
• 作为产物：
  描述：

  4-羟甲基-3-硝基苯甲酸 在 吡啶 、 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 26.0h， 生成 4-(dodecylcarbamoyl)-2-nitrobenzyl (4-nitrophenyl) carbonate
  参考文献：
  名称：

  Constrained and UV-activatable cell-penetrating peptides for intracellular delivery of liposomes

  摘要：

  Herein we report on the development of a novel method of constraining a cell-penetrating peptide, which can be used to trigger transport of liposomes into cells upon in this case radiation with UV-light. A cell-penetrating peptide, which was modified on both termini with an alkyl chain, was anchored to the liposomal surface in a constrained and deactivated form. Since one of the two alkyl chains was connected to the peptide via a UV-cleavable linker, disconnection of this alkyl chain upon irradiation led to the exposure of the cell-penetrating peptide, and mediated the transport of the entire liposome particle into cells. (C) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jconrel.2012.10.008