4-methyl-N-[2-oxo-3-(triphenyl-λ⁵-phosphoranylidene)prop-1-yl]-N-(1-phenylbut-3-en-1-yl)benzenesulfonamide | 882529-63-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methyl-N-[2-oxo-3-(triphenyl-λ⁵-phosphoranylidene)prop-1-yl]-N-(1-phenylbut-3-en-1-yl)benzenesulfonamide
• 英文别名: 4-methyl-N-[2-oxo-3-(triphenyl-lambda5-phosphanylidene)propyl]-N-(1-phenylbut-3-enyl)benzenesulfonamide；4-methyl-N-[2-oxo-3-(triphenyl-λ5-phosphanylidene)propyl]-N-(1-phenylbut-3-enyl)benzenesulfonamide
• CAS: 882529-63-7
• 化学式: C₃₈H₃₆NO₃PS
• 分子量: 617.749
• InChiKey: VNJLZRVFMRRNEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  44
• 可旋转键数：
  12
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  62.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-methyl-N-[2-oxo-3-(triphenyl-λ⁵-phosphoranylidene)prop-1-yl]-N-(1-phenylbut-3-en-1-yl)benzenesulfonamide 在 RuCl2(1,3-dimesityl-imidazolidin-2-yl)(PCy3)(=CHPh) 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 为溶剂， 反应 15.0h， 生成 1-[(4-methylphenyl)-1-sulfonyl]-7-phenyl-2,3,6,7-tetrahydroazepin-3-one
  参考文献：
  名称：

  Synthesis of 3-oxooxa- and 3-oxoazacycloalk-4-enes by ring-closing metathesis. Application to the synthesis of an inhibitor of cathepsin K

  摘要：

  3-Oxooxa- and 3-oxoazacycloalk-4-enes were obtained with good yield from 1-(omega-alkenyloxy)- and 1-(omega-alkenylamino)-but-3-en-2-ones by using a ring-closing metathesis. This methodology has been used to synthesize an inhibitor of cathepsin K. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.03.066
• 作为产物：
  描述：

  N-亚苄基-4-甲基苯磺酰胺 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 5.0h， 生成 4-methyl-N-[2-oxo-3-(triphenyl-λ⁵-phosphoranylidene)prop-1-yl]-N-(1-phenylbut-3-en-1-yl)benzenesulfonamide
  参考文献：
  名称：

  Synthesis of 3-oxooxa- and 3-oxoazacycloalk-4-enes by ring-closing metathesis. Application to the synthesis of an inhibitor of cathepsin K

  摘要：

  3-Oxooxa- and 3-oxoazacycloalk-4-enes were obtained with good yield from 1-(omega-alkenyloxy)- and 1-(omega-alkenylamino)-but-3-en-2-ones by using a ring-closing metathesis. This methodology has been used to synthesize an inhibitor of cathepsin K. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.03.066

文献信息

• Synthesis of 3-Oxoazacyclohept-4-enes by Ring-closing Metathesis. Application to the Synthesis of an Inhibitor of Ca- thepsin K
  作者：Janine Cossy、Catherine Taillier、Thomas Hameury、Véronique Bellosta

  DOI：10.3987/com-05-s(t)65

  日期：——
• Synthesis of 3-oxooxa- and 3-oxoazacycloalk-4-enes by ring-closing metathesis. Application to the synthesis of an inhibitor of cathepsin K
  作者：Catherine Taillier、Thomas Hameury、Véronique Bellosta、Janine Cossy

  DOI：10.1016/j.tet.2007.03.066

  日期：2007.5

  3-Oxooxa- and 3-oxoazacycloalk-4-enes were obtained with good yield from 1-(omega-alkenyloxy)- and 1-(omega-alkenylamino)-but-3-en-2-ones by using a ring-closing metathesis. This methodology has been used to synthesize an inhibitor of cathepsin K. (C) 2007 Elsevier Ltd. All rights reserved.