2-(4-cyanophenyl)acrylic acid | 934476-97-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-cyanophenyl)acrylic acid
• 英文别名: 2-(4-Cyanophenyl)prop-2-enoic acid
• CAS: 934476-97-8
• 化学式: C₁₀H₇NO₂
• 分子量: 173.171
• InChiKey: GHGDQPZVDIDYOI-UHFFFAOYSA-N

物化性质

• 沸点：
  364.0±25.0 °C(Predicted)
• 密度：
  1.24±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  61.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(4-cyanophenyl)acrylic acid 在 盐酸 、 氨 作用下， 以 乙醇 、 氯仿 为溶剂， 生成
  参考文献：
  名称：

  3-Mercaptopropionic acids as efficacious inhibitors of activated thrombin activatable fibrinolysis inhibitor (TAFIa)

  摘要：

  A novel series of cyclic potent, selective, small molecule, thiol-based inhibitors of activated thrombin activatable fibrinolysis inhibitor (TAFIa) and the crystal structures of TAFIa inhibitors bound to porcine pancreatic carboxypeptidase B are described. Three series of cyclic arginine and lysine mimetic inhibitors vary significantly in their selectivity against other human basic carboxypeptidases, carboxypeptidase N and carboxypeptidase B. (-)2a displays TAFIa IC50 = 3 nM and 600-fold selectivity against CPN. Inhibition of TAFIa with (rac)2a resulted in dose dependent acceleration of human plasma clot lysis in vitro and was efficacious as an adjunct to tPA in an in vivo rabbit jugular vein thrombolysis model.

  DOI：

  10.1016/j.bmcl.2006.11.078
• 作为产物：
  描述：

  ethyl 2-(4-cyanophenyl)propenoate 在 sodium hydroxide 作用下， 以 水 为溶剂， 反应 1.0h， 生成 2-(4-cyanophenyl)acrylic acid
  参考文献：
  名称：

  对映选择性 [3 + 2] 联烯与二肽衍生的膦催化的丙烯酸酯环加成：轻松创建含有四元立体中心的功能化环戊烯

  摘要：

  设计并制备了一个新的基于二肽的手性膦家族。D-Thr-L-tert-Leu 衍生的催化剂 4c 以区域专一性和立体选择性的方式促进了烯丙酸酯的 [3 + 2] 环加成反应到 α-取代的丙烯酸酯，以高产率和优异的对映选择性提供具有四元立体中心的官能化环戊烯。

  DOI：

  10.1021/ja1106282

文献信息

• Enantioselective [3 + 2] Cycloaddition of Allenes to Acrylates Catalyzed by Dipeptide-Derived Phosphines: Facile Creation of Functionalized Cyclopentenes Containing Quaternary Stereogenic Centers
  作者：Xiaoyu Han、Youqing Wang、Fangrui Zhong、Yixin Lu

  DOI：10.1021/ja1106282

  日期：2011.2.16

  A new family of dipeptide-based chiral phosphines was designed and prepared. D-Thr-L-tert-Leu-derived catalyst 4c promoted [3 + 2] cycloaddition of allenoates to α-substituted acrylates in a regiospecific and stereoselective manner, furnishing functionalized cyclopentenes with quaternary stereogenic centers in high yields and with excellent enantioselectivities.

  设计并制备了一个新的基于二肽的手性膦家族。D-Thr-L-tert-Leu 衍生的催化剂 4c 以区域专一性和立体选择性的方式促进了烯丙酸酯的 [3 + 2] 环加成反应到 α-取代的丙烯酸酯，以高产率和优异的对映选择性提供具有四元立体中心的官能化环戊烯。
• Stilbene derivative and preparation method thereof
  申请人：BEIJING INSTITUTE OF TECHNOLOGY

  公开号：US10829466B2

  公开（公告）日：2020-11-10

  A stilbene derivative, which is a compound of the following general formula I or general formula II, or an acceptable salt formed by the compound of the general formula I or the general formula II and an inorganic or organic acid; wherein, in the general formula I or the general formula II, the atom represented by X is a hydrogen atom or a halogen atom; the substituent represented by R is C1-C6 alkyl, 1-6-membered heteroalkyl, C2-C4 alkenyl, C2-C4 alkynyl, C3-C6 cycloalkyl, substituted C3-C6 cycloalkyl, 3-6-membered heterocycloalkyl, substituted 3-6-membered heterocycloalkyl, 5-18-membered aryl, substituted 5-18-membered aryl, 5-18-membered heteroaryl, or substituted 5-18-membered heteroaryl.

  二苯乙烯衍生物，即以下通式 I 或通式 II 的化合物，或由通式 I 或通式 II 的化合物与无机酸或有机酸形成的可接受的盐； 其中，在通式 I 或通式 II 中，X 代表的原子是氢原子或卤素原子； R 所代表的取代基是 C1-C6 烷基、1-6 元杂烷基、C2-C4 烯基、C2-C4 炔基、C3-C6 环烷基、取代的 C3-C6 环烷基、3-6 元杂环烷基、取代的 3-6 元杂环烷基、5-18 元芳基、取代的 5-18 元芳基、5-18 元杂芳基或取代的 5-18 元杂芳基。
• Solid electrolyte composition, solid electrolyte-containing sheet, all-solid state secondary battery, and methods for manufacturing solid electrolyte composition, solid electrolyte-containing sheet, all-solid state secondary battery
  申请人：FUJIFILM Corporation

  公开号：US10833351B2

  公开（公告）日：2020-11-10

  Provided are a solid electrolyte composition containing an inorganic solid electrolyte having a conductivity for ions of metals belonging to Group I or II of the periodic table and a compound having an anionic polymerizable functional group, a solid electrolyte-containing sheet containing an inorganic solid electrolyte having a conductivity for ions of metals belonging to Group I or II of the periodic table and an anionic polymer which bonds to the inorganic solid electrolyte, and an all-solid state secondary battery, and methods for manufacturing the solid electrolyte composition, the solid electrolyte-containing sheet, and the all-solid state secondary battery.

  本发明提供了一种固体电解质组合物，该组合物含有对属于元素周期表第 I 组或第 II 组的金属离子具有导电性的无机固体电解质和具有阴离子可聚合官能团的化合物、一种含固体电解质的薄片，其中含有对属于元素周期表第I或第II族的金属离子具有导电性的无机固体电解质和一种与无机固体电解质结合的阴离子聚合物，以及一种全固态二次电池，以及制造该固体电解质组合物、含固体电解质的薄片和全固态二次电池的方法。
• Sulfonate-Modified Picolinamide Diphosphine: A Ligand for Room-Temperature Palladium-Catalyzed Hydrocarboxylation in Water with High Branched Selectivity
  作者：Ding Liu、Tong Ru、Zhixin Deng、Luyun Zhang、Yingtang Ning、Fen-Er Chen

  DOI：10.1021/acscatal.3c03372

  日期：2023.10.6
• SOLID ELECTROLYTE COMPOSITION, SOLID ELECTROLYTE-CONTAINING SHEET, ALL-SOLID STATE SECONDARY BATTERY, AND METHODS FOR MANUFACTURING SOLID ELECTROLYTE COMPOSITION, SOLID ELECTROLYTE-CONTAINING SHEET, ALL-SOLID STATE SECONDARY BATTERY
  申请人：FUJIFILM Corporation

  公开号：US20190006700A1

  公开（公告）日：2019-01-03

  Provided are a solid electrolyte composition containing an inorganic solid electrolyte having a conductivity for ions of metals belonging to Group I or II of the periodic table and a compound having an anionic polymerizable functional group, a solid electrolyte-containing sheet containing an inorganic solid electrolyte having a conductivity for ions of metals belonging to Group I or II of the periodic table and an anionic polymer which bonds to the inorganic solid electrolyte, and an all-solid state secondary battery, and methods for manufacturing the solid electrolyte composition, the solid electrolyte-containing sheet, and the all-solid state secondary battery.