1,2-bis(2-propyl-1-benzothiophene-1,1-dioxide-2-yl)perfluorocyclopentene | 1082604-20-3

• 分子结构分类: 有机化合物 - 苯类化合物
• 英文名称: 1,2-bis(2-propyl-1-benzothiophene-1,1-dioxide-2-yl)perfluorocyclopentene
• CAS: 1082604-20-3
• 化学式: C₂₇H₂₂F₆O₄S₂
• 分子量: 588.592
• InChiKey: BKXPOPWAKHIYGR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  1,2-bis(2-propyl-1-benzothiophene-2-yl)perfluorocyclopentene 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以71%的产率得到1,2-bis(2-propyl-1-benzothiophene-1,1-dioxide-2-yl)perfluorocyclopentene
  参考文献：
  名称：

  Superparamagnetic iron oxide nanoparticles with photoswitchable fluorescence

  摘要：

  将超顺磁性氧化铁纳米颗粒与硫氧化二芳基乙烯分子结合形成了一种新型多功能纳米系统，其中荧光性能以及絮凝和分散分别通过光照射和外部磁场可逆地切换。

  DOI：

  10.1039/b807462c

文献信息

• 3-Mercaptopropionic acid-mediated synthesis of peptide and protein thioesters
  作者：Jaskiranjit Kang、Jonathan P. Richardson、Derek Macmillan

  DOI：10.1039/b815888f

  日期：——

  Peptides and proteins fragment sequence-specifically in the presence of 3-mercaptopropionic acid to afford thioesters which can be used in native chemical ligation reactions.

  在3-巯基丙酸的存在下，肽和蛋白质可特异性地断裂生成硫酯，这些硫酯可用于天然化学连接反应。
• Discovery of the first non-ATP competitive IGF-1R kinase inhibitors: Advantages in comparison with competitive inhibitors
  作者：Dominique Lesuisse、Jacques Mauger、Conception Nemecek、Sébastien Maignan、Janine Boiziau、Greg Harlow、Augustin Hittinger、Swen Ruf、Hartmut Strobel、Anil Nair、Kurt Ritter、Jean-Luc Malleron、Anne Dagallier、Youssef El-Ahmad、Jean-Pierre Guilloteau、Houlfa Guizani、Hervé Bouchard、Corinne Venot

  DOI：10.1016/j.bmcl.2011.03.003

  日期：2011.4

  A new series of IGF-1R inhibitors related to hydantoins were identified from a lead originating from HTS. Their noncompetitive property as well as their slow binding characteristics provided a series of compounds with unique selectivity and excellent cellular activities.

  从源自HTS的铅中鉴定了一系列与乙内酰脲相关的IGF-1R抑制剂。它们的非竞争性质以及缓慢的结合特性为一系列化合物提供了独特的选择性和出色的细胞活性。
• Probing Protein Surfaces: QSAR Analysis with Helix Mimetics
  作者：Valeria Azzarito、Philip Rowell、Anna Barnard、Thomas A. Edwards、Andrew Macdonald、Stuart L. Warriner、Andrew J. Wilson

  DOI：10.1002/cbic.201500504

  日期：2016.4.15

  Rationalising behaviour: Using a helix mimetic based on an oligoamide scaffold, we have exploited a modular synthesis to access compounds that can readily be used to understand the noncovalent determinants of hDM2 recognition by cell‐active p53/hDM2 inhibitors.

  合理化行为：使用基于寡酰胺支架的螺旋模拟物，我们利用模块化合成来获取化合物，这些化合物可以很容易地用于理解细胞活性 p53/ h DM2 抑制剂识别h DM2 的非共价决定因素。
• Stereocontrolled protein surface recognition using chiral oligoamide proteomimetic foldamers
  作者：Valeria Azzarito、Jennifer A. Miles、Julie Fisher、Thomas A. Edwards、Stuart L. Warriner、Andrew J. Wilson

  DOI：10.1039/c4sc03559c

  日期：——

  An oligoamide helix mimicking foldamer with well-defined conformation is shown to recognize its target protein hDM2 in a manner that depends upon the composition, spatial projection and stereochemistry of functional groups appended to the scaffold.

  一种模拟螺旋结构的寡酰胺折叠体，具有明确定义的构象，被证明可以识别其靶蛋白hDM2，这种识别方式取决于附加到支架上的功能基团的组成、空间投影和立体化学特性。
• Synthesis and protonation behavior of a water-soluble N-fused porphyrin: Conjugation with an oligoarginine by click chemistry
  作者：Yoshiya Ikawa、Hiroyuki Harada、Motoki Toganoh、Hiroyuki Furuta

  DOI：10.1016/j.bmcl.2009.03.066

  日期：2009.5

  A water-soluble derivative of N-fused porphyrin (NFP) possessing a nona-arginine (R9) peptide tail was synthesized for the first time by a Cu(I)-catalyzed azide-alkyne 'click' reaction. In aqueous solution, at pH 8, the conjugated molecule (NFP-R9) exists as free base and protonated below pH < 6.5 to form monoprotonated species dominantly, and diprotonated one below pH < 2.3, while such clear two-step protonation behavior was not observed in the DMF solution. (c) 2009 Elsevier Ltd. All rights reserved.