(S)-N2-(3-chloro-4-methoxy-6-methylphenyl)-5-fluoro-N4-(2-methyl-3-oxo-2H,4H-benz[1,4]oxazin-6-yl)-2,4-pyrimidinediamine | 841288-75-3

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: (S)-N2-(3-chloro-4-methoxy-6-methylphenyl)-5-fluoro-N4-(2-methyl-3-oxo-2H,4H-benz[1,4]oxazin-6-yl)-2,4-pyrimidinediamine
• 英文别名: (2S)-6-[[2-(5-chloro-4-methoxy-2-methylanilino)-5-fluoropyrimidin-4-yl]amino]-2-methyl-4H-1,4-benzoxazin-3-one
• CAS: 841288-75-3
• 化学式: C₂₁H₁₉ClFN₅O₃
• 分子量: 443.865
• InChiKey: HMPBDSREZRUIIO-NSHDSACASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  97.4
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• 2,4-Pyrimidinediamine Compounds And Uses As Anti-Proliferative Agents
  申请人：Argade Ankush

  公开号：US20080009484A1

  公开（公告）日：2008-01-10

  The present invention provides 2,4-pyrimidinediamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferative diseases such as tumorigenic cancers.
• 2,4-Pyrimidinediamine Compounds and Uses as Anti-Proliferative Agents
  申请人：Argade Ankush

  公开号：US20110190271A1

  公开（公告）日：2011-08-04

  The present invention provides 2,4-pyrimidinediamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferative diseases such as tumorigenic cancers.
• US7884111B2
  申请人：——

  公开号：US7884111B2

  公开（公告）日：2011-02-08
• US8809341B2
  申请人：——

  公开号：US8809341B2

  公开（公告）日：2014-08-19
• US9598432B2
  申请人：——

  公开号：US9598432B2

  公开（公告）日：2017-03-21